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GPCR

NameAlpha-2B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra2b
SynonymADRA2L1
alpha2B-adrenoceptor
alpha2B
alpha2-C2
alpha-2BAR
[ Show all ]
DiseaseN/A for non-human GPCRs
Length453
Amino acid sequenceMSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProtP19328
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL266
IUPHAR26
DrugBankN/A

Ligand

Namethioridazine
Molecular formulaC21H26N2S2
IUPAC name10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine
Molecular weight370.573
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.9
SynonymsNCGC00016059-08
API0003283
NINDS_000066
BSPBio_000295
Prestwick0_000078
[ Show all ]
Inchi KeyKLBQZWRITKRQQV-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
PubChem CID5452
ChEMBLCHEMBL479
IUPHAR100
BindingDB50002338
DrugBankDB00679

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki259.0 nMPMID1656026BindingDB

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