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GPCR

NameFree fatty acid receptor 1
SpeciesMus musculus (Mouse)
GeneFfar1
SynonymFFA1 receptor
FFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
DiseaseN/A for non-human GPCRs
Length300
Amino acid sequenceMDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
UniProtQ76JU9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5411
IUPHARN/A
DrugBankN/A

Ligand

NameBDBM50344083
Molecular formulaC20H17NO4
IUPAC name4-hydroxy-5-[1-(4-phenylmethoxyphenyl)but-2-ynyl]-3H-1,3-oxazol-2-one
Molecular weight335.359
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.6
Synonymsrac-5-(1-(4-(benzyloxy)phenyl)but-2-ynyl)oxazolidine-2,4-dione
Inchi KeyKMOHPLLVICCTRS-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H17NO4/c1-2-6-17(18-19(22)21-20(23)25-18)15-9-11-16(12-10-15)24-13-14-7-4-3-5-8-14/h3-5,7-12,17,22H,13H2,1H3,(H,21,23)
PubChem CID91932227
ChEMBLN/A
IUPHARN/A
BindingDB50344083
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC503707.0 nMPMID21514824BindingDB

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