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Name | Alpha-1D adrenergic receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Adra1d |
Synonym | ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 561 |
Amino acid sequence | MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI |
UniProt | P23944 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL326 |
IUPHAR | 24 |
DrugBank | N/A |
Name | CHEMBL323440 |
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Molecular formula | C15H19N3O2S |
IUPAC name | N-[5-(1H-imidazol-5-yl)-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide |
Molecular weight | 305.396 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.1 |
Synonyms | SCHEMBL7102120 |
Inchi Key | KOIYXDHDIOIQBW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H19N3O2S/c1-10-6-7-13(18-21(2,19)20)11-4-3-5-12(15(10)11)14-8-16-9-17-14/h6-9,12,18H,3-5H2,1-2H3,(H,16,17) |
PubChem CID | 9796526 |
ChEMBL | CHEMBL323440 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 2691.53 nM | PMID15163201 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218