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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL2165195 |
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Molecular formula | C19H23ClFN3O3 |
IUPAC name | 5-chloro-1-[(1R)-1-cyclopropyl-2-methoxyethyl]-3-[4-(fluoromethoxy)-2,5-dimethylanilino]pyrazin-2-one |
Molecular weight | 395.859 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 3.5 |
Synonyms | BDBM50395833 |
Inchi Key | AYICDFKLBCUUCO-HNNXBMFYSA-N |
Inchi ID | InChI=1S/C19H23ClFN3O3/c1-11-7-16(27-10-21)12(2)6-14(11)22-18-19(25)24(8-17(20)23-18)15(9-26-3)13-4-5-13/h6-8,13,15H,4-5,9-10H2,1-3H3,(H,22,23)/t15-/m0/s1 |
PubChem CID | 71455126 |
ChEMBL | CHEMBL2165195 |
IUPHAR | N/A |
BindingDB | 50395833 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 4.1 nM | PMID23010264 | BindingDB,ChEMBL |
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