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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL2165195
Molecular formulaC19H23ClFN3O3
IUPAC name5-chloro-1-[(1R)-1-cyclopropyl-2-methoxyethyl]-3-[4-(fluoromethoxy)-2,5-dimethylanilino]pyrazin-2-one
Molecular weight395.859
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.5
SynonymsBDBM50395833
Inchi KeyAYICDFKLBCUUCO-HNNXBMFYSA-N
Inchi IDInChI=1S/C19H23ClFN3O3/c1-11-7-16(27-10-21)12(2)6-14(11)22-18-19(25)24(8-17(20)23-18)15(9-26-3)13-4-5-13/h6-8,13,15H,4-5,9-10H2,1-3H3,(H,22,23)/t15-/m0/s1
PubChem CID71455126
ChEMBLCHEMBL2165195
IUPHARN/A
BindingDB50395833
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC504.1 nMPMID23010264BindingDB,ChEMBL

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