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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Bombesin receptor subtype-3
Species	Mus musculus (Mouse)
Gene	Brs3
Synonym	bb3 BB3 receptor bombesin like receptor 3 bombesin receptor subtype-3 BRS-3
Disease	N/A for non-human GPCRs
Length	399
Amino acid sequence	MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
UniProt	O54798
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075140
IUPHAR	40
DrugBank	N/A

Ligand

Name	CHEMBL2179915
Molecular formula	C26H27F4N3O3S
IUPAC name	2-[6-(4-tert-butylphenyl)sulfonyl-7-fluoro-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-8-yl]propan-2-ol
Molecular weight	537.574
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	5.4
Synonyms	BDBM50400250
Inchi Key	KPKMIOYZORPDNH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H27F4N3O3S/c1-24(2,3)16-7-9-17(10-8-16)37(35,36)33-14-15-6-13-20(26(28,29)30)32-23(15)31-19-12-11-18(25(4,5)34)21(27)22(19)33/h6-13,34H,14H2,1-5H3,(H,31,32)
PubChem CID	71451990
ChEMBL	CHEMBL2179915
IUPHAR	N/A
BindingDB	50400250
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	134.0 nM	PMID24900283	BindingDB,ChEMBL
max activation	97.0 %	PMID24900283	ChEMBL

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