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GPCR

NameProstaglandin E2 receptor EP1 subtype
SpeciesHomo sapiens (Human)
GenePTGER1
SynonymPGE receptor EP1 subtype
EP1 receptor
prostaglandin E receptor 1 (subtype EP1), 42kDa
Prostanoid EP1 receptor
EP1 prostanoid receptor
[ Show all ]
DiseaseUnspecified
Thrombosis
Pollakiuria
Pain
Length402
Amino acid sequenceMSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProtP34995
Protein Data BankN/A
GPCR-HGmod modelP34995
3D structure modelThis predicted structure model is from GPCR-EXP P34995.
BioLiPN/A
Therapeutic Target DatabaseT15497
ChEMBLCHEMBL1811
IUPHAR340
DrugBankBE0000064

Ligand

NameCHEMBL233975
Molecular formulaC24H19ClN4O
IUPAC name5-[2-(5-chloro-2-phenylmethoxyphenyl)-5-methylpyrrol-1-yl]-2H-benzotriazole
Molecular weight414.893
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.6
SynonymsBDBM50423123
Inchi KeyAYJUIAGESMWXBZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H19ClN4O/c1-16-7-11-23(29(16)19-9-10-21-22(14-19)27-28-26-21)20-13-18(25)8-12-24(20)30-15-17-5-3-2-4-6-17/h2-14H,15H2,1H3,(H,26,27,28)
PubChem CID44432369
ChEMBLCHEMBL233975
IUPHARN/A
BindingDB50423123
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5025.0 nMPMID17196385BindingDB
IC5025.12 nMPMID17196385ChEMBL

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