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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Mus musculus (Mouse)
Gene	Npy5r
Synonym	food intake receptor neuropeptide Y receptor type 5 NPY-Y5 receptor NPY5-R NPYY5-R Y5 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
UniProt	O70342
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3802
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2159163
Molecular formula	C20H23N3O3S
IUPAC name	2-phenyl-4-(6-propan-2-ylsulfonyl-1H-benzimidazol-2-yl)morpholine
Molecular weight	385.482
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	BDBM50394213
Inchi Key	KRNDNXJDJOWMSY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23N3O3S/c1-14(2)27(24,25)16-8-9-17-18(12-16)22-20(21-17)23-10-11-26-19(13-23)15-6-4-3-5-7-15/h3-9,12,14,19H,10-11,13H2,1-2H3,(H,21,22)
PubChem CID	71453236
ChEMBL	CHEMBL2159163
IUPHAR	N/A
BindingDB	50394213
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.33 nM	PMID23025998	BindingDB,ChEMBL

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