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GPCR

NameC-C chemokine receptor type 3
SpeciesHomo sapiens (Human)
GeneCCR3
SynonymMIP-1alphaRL-2 (mouse)
Eosinophil eotaxin receptor
CKR3
chemokine (C-C motif) receptor 3
CD193
[ Show all ]
DiseaseAllergic asthma
Allergic rhinitis
Asthma
Length355
Amino acid sequenceMTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProtP51677
Protein Data BankN/A
GPCR-HGmod modelP51677
3D structure modelThis predicted structure model is from GPCR-EXP P51677.
BioLiPN/A
Therapeutic Target DatabaseT02752, T85228
ChEMBLCHEMBL3473
IUPHAR60
DrugBankN/A

Ligand

NameCHEMBL2158790
Molecular formulaC28H35Cl2FN2O3
IUPAC name(2S)-2-[4-[[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)-2-methylpropanoic acid
Molecular weight537.497
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.5
SynonymsBDBM50394157
SCHEMBL180056
Inchi KeyAYPGYVOWMUSFPT-NDEPHWFRSA-N
Inchi IDInChI=1S/C28H35Cl2FN2O3/c1-19-25(8-7-24(29)26(19)30)36-23-11-13-32(14-12-23)18-21-9-15-33(16-10-21)28(2,27(34)35)17-20-3-5-22(31)6-4-20/h3-8,21,23H,9-18H2,1-2H3,(H,34,35)/t28-/m0/s1
PubChem CID66615627
ChEMBLCHEMBL2158790
IUPHARN/A
BindingDB50394157
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.1995 nMPMID23021991ChEMBL
Ki0.2 nMPMID23021991BindingDB

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