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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Canis lupus familiaris (Dog)
Gene	DRD2
Synonym	Dopamine D2 receptor
Disease	N/A for non-human GPCRs
Length	443
Amino acid sequence	MDPLNLSWYDDDLESQNWSRPFNGSEGKPGKPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTERSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTADSPAKPEKNGHAKDHPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCECNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	Q9GJU1
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2703
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Alizapride
Molecular formula	C16H21N5O2
IUPAC name	6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-3H-benzotriazole-5-carboxamide
Molecular weight	315.377
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.6
Synonyms	KB-257972 N-((1-Allylpyrrolidin-2-yl)methyl)-6-methoxy-1H-benzo[d][1,2,3]triazole-5-carboxamide ST24048223 1H-Benzotriazole-5-carboxamide, 6-methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)- 6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide Alizaprid AN-6544 CHEBI:94316 Liticum N-[(1-allylpyrrolidin-2-yl)methyl]-6-methoxy-2H-benzotriazole-5-carboxamide AC-22579 BC222067 D07102 EINECS 261-710-6 MS-5080 Plitican (TN) 6-Methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1H-benzotriazole-5-carboxamide AK116438 Alizapridum BRN 6432438 Limican N-((allyl-1-pyrrolidinyl-2)-methyl)methoxy-2-azimido-4,5-benzamide Superan 338A931 6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-2H-1,2,3-benzotriazole-5-carboxamide Alizaprida API0001412 LS-41534 NCGC00246965-01 59338-93-1 AC1L28ZD Alizapride (INN) BCP15799 FT-0621964 N-((1-Allyl-2-pyrrolidinyl)methyl)-6-methoxy-1H-benzotriazole-5-carboxamide SCHEMBL48936 6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide AKOS016010366 Alizapridum [INN-Latin] C16H21N5O2 Litican n-[(1-allyl-2-pyrrolidinyl)methyl]-6-methoxy-1h-benzotriazole-5-carboxamide Vergentan 4CH-024669 8836AB Alizaprida [INN-Spanish] AX8112951 CHEMBL290194 DB01425 MS 5080 Plitican 6-Methoxy-1H-benzotriazole-5-carboxylic acid (1-allyl-pyrrolidin-2-ylmethyl)-amide AC1Q5GH8 Alizapride [INN] BDBM50023804 [ Show all ]
Inchi Key	KSEYRUGYKHXGFW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20)
PubChem CID	135413504
ChEMBL	CHEMBL290194
IUPHAR	N/A
BindingDB	50023804
DrugBank	DB01425
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	0.3 mg.kg-1	PMID3397992	ChEMBL

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