You can:
Name | Neuropeptide Y receptor type 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | NPY1R |
Synonym | neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor [ Show all ] |
Disease | Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder [ Show all ] |
Length | 384 |
Amino acid sequence | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI |
UniProt | P25929 |
Protein Data Bank | 5zbh |
GPCR-HGmod model | P25929 |
3D structure model | This structure is from PDB ID 5zbh. |
BioLiP | BL0411971 |
Therapeutic Target Database | T89213 |
ChEMBL | CHEMBL4777 |
IUPHAR | 305 |
DrugBank | N/A |
Name | MLS000552453 |
---|---|
Molecular formula | C15H18Cl2N4O2S |
IUPAC name | 4-[2-(2,4-dichlorophenoxy)ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine |
Molecular weight | 389.295 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 4.9 |
Synonyms | AC1LZ7HI 4-[2-(2,4-dichlorophenoxy)ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine SMR000145968 4-{[2-(2,4-dichlorophenoxy)ethyl]sulfanyl}-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine HMS2539O13 [ Show all ] |
Inchi Key | AYTQUIGQFYRMRK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H18Cl2N4O2S/c1-4-22-14-18-13(21(2)3)19-15(20-14)24-8-7-23-12-6-5-10(16)9-11(12)17/h5-6,9H,4,7-8H2,1-3H3 |
PubChem CID | 1894428 |
ChEMBL | CHEMBL1431004 |
IUPHAR | N/A |
BindingDB | 42493 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5537.0 nM | , PubChem BioAssay data set | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218