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Name | Alpha-1A adrenergic receptor |
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Species | Oryctolagus cuniculus (Rabbit) |
Gene | ADRA1A |
Synonym | Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MVFLSGNASDSSNCTHPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVISIDRYIGVSYPLRYPTIVTQRRGLRALLCVWAFSLVISVGPLFGWRQPAPDDETICQINEEPGYVLFSALGSFYVPLTIILAMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGVASAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALGYTLHAPSQALEGQHKDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPRGSARITVPKDQSACTTARVRSKSFLQVCCCVGPSTPNPGENHQVPTIKIHTISLSENGEEV |
UniProt | O02824 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3637 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL327872 |
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Molecular formula | C23H30N6O2 |
IUPAC name | 5-cyano-2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-N,N-dimethylpyridine-3-carboxamide |
Molecular weight | 422.533 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 2.9 |
Synonyms | N/A |
Inchi Key | KVWRYFZHOACXMA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H30N6O2/c1-27(2)23(30)19-15-18(16-24)17-26-22(19)25-9-6-10-28-11-13-29(14-12-28)20-7-4-5-8-21(20)31-3/h4-5,7-8,15,17H,6,9-14H2,1-3H3,(H,25,26) |
PubChem CID | 10574245 |
ChEMBL | CHEMBL327872 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 0.7943 nM | PMID9276013 | ChEMBL |
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