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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL274564
Molecular formulaC40H54Br2N4O4
IUPAC name[3-(1,3-dioxobenzo[de]isoquinolin-2-yl)-2,2-dimethylpropyl]-[6-[[3-(1,3-dioxoisoindol-2-yl)-2,2-dimethylpropyl]-dimethylazaniumyl]hexyl]-dimethylazanium;dibromide
Molecular weight814.704
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogPNone
SynonymsN/A
Inchi KeyKYNMWSRJPWQATB-UHFFFAOYSA-L
Inchi IDInChI=1S/C40H54N4O4.2BrH/c1-39(2,25-41-35(45)30-19-11-12-20-31(30)36(41)46)27-43(5,6)23-13-9-10-14-24-44(7,8)28-40(3,4)26-42-37(47)32-21-15-17-29-18-16-22-33(34(29)32)38(42)48;;/h11-12,15-22H,9-10,13-14,23-28H2,1-8H3;2*1H/q+2;;/p-2
PubChem CID11828872
ChEMBLCHEMBL274564
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
-logKa7.41 -PMID12620079ChEMBL
EC5018.62 nMPMID12620079ChEMBL
p alpha0.56 -PMID15771463ChEMBL
p alphaKa7.97 -PMID12620079ChEMBL
pAlpha0.56 -PMID12620079ChEMBL
pEC50 diss7.73 -PMID15771463ChEMBL
pKA7.41 -PMID15771463ChEMBL

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