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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL1080907
Molecular formula	C28H27N3O2
IUPAC name	[(3S)-4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl]-[4-(2-methylphenyl)phenyl]methanone
Molecular weight	437.543
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.9
Synonyms	BDBM50312766 (S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2''-methylbiphenyl-4-yl)methanone
Inchi Key	LADSERODBYZUAW-FQEVSTJZSA-N
Inchi ID	InChI=1S/C28H27N3O2/c1-19-5-3-4-6-25(19)21-7-10-23(11-8-21)27(32)30-15-16-31(20(2)18-30)28(33)24-12-9-22-13-14-29-26(22)17-24/h3-14,17,20,29H,15-16,18H2,1-2H3/t20-/m0/s1
PubChem CID	46880631
ChEMBL	CHEMBL1080907
IUPHAR	N/A
BindingDB	50312766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	31.0 %	PMID20137933	ChEMBL

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