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Name | Galanin receptor type 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | GALR1 |
Synonym | GAL1-R GALNR GALNR1 GALR-1 GAL1 receptor |
Disease | Epileptic seizures |
Length | 349 |
Amino acid sequence | MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV |
UniProt | P47211 |
Protein Data Bank | N/A |
GPCR-HGmod model | P47211 |
3D structure model | This predicted structure model is from GPCR-EXP P47211. |
BioLiP | N/A |
Therapeutic Target Database | T78581 |
ChEMBL | CHEMBL4894 |
IUPHAR | 243 |
DrugBank | N/A |
Name | CHEMBL1922001 |
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Molecular formula | C28H34F3N7 |
IUPAC name | N-(2,5-dimethylphenyl)-6-piperidin-1-yl-2-[4-[3-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl]pyrimidin-4-amine |
Molecular weight | 525.624 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 1 |
XlogP | 6.7 |
Synonyms | BDBM50358660 SCHEMBL10144203 |
Inchi Key | LCAIIGMHVYEWEQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H34F3N7/c1-20-9-10-21(2)23(18-20)33-24-19-25(36-12-4-3-5-13-36)35-27(34-24)38-15-7-14-37(16-17-38)26-22(28(29,30)31)8-6-11-32-26/h6,8-11,18-19H,3-5,7,12-17H2,1-2H3,(H,33,34,35) |
PubChem CID | 57395994 |
ChEMBL | CHEMBL1922001 |
IUPHAR | N/A |
BindingDB | 50358660 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 3900.0 nM | PMID22018787 | BindingDB,ChEMBL |
Inhibition | 60.0 % | PMID22018787 | ChEMBL |
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