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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCHEMBL182410
Molecular formulaC25H32ClN3O3
IUPAC name3-[1-[3-(2-chloro-5-methylphenoxy)-2-hydroxyhexyl]piperidin-4-yl]-1H-benzimidazol-2-one
Molecular weight457.999
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.7
SynonymsBDBM50159915
1-{1-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxy-hexyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
Inchi KeyAZPDSENEWXRPQS-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H32ClN3O3/c1-3-6-23(32-24-15-17(2)9-10-19(24)26)22(30)16-28-13-11-18(12-14-28)29-21-8-5-4-7-20(21)27-25(29)31/h4-5,7-10,15,18,22-23,30H,3,6,11-14,16H2,1-2H3,(H,27,31)
PubChem CID44391133
ChEMBLCHEMBL182410
IUPHARN/A
BindingDB50159915
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501058.0 nMPMID15664818BindingDB,ChEMBL
Ki20.0 nMPMID15664818BindingDB,ChEMBL
Response97.0 %PMID15664818ChEMBL

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