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Name | Endothelin-1 receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Ednra |
Synonym | endothelin A receptor Endothelin receptor type A {ECO:0000312|RGD:2535} ENDOR endothelin-1 receptor ET-A [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 426 |
Amino acid sequence | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN |
UniProt | P26684 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4566 |
IUPHAR | 219 |
DrugBank | N/A |
Name | CHEMBL367208 |
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Molecular formula | C29H34N6O4 |
IUPAC name | 5-methyl-2-[(1R)-2-(1-methylindol-3-yl)-1-[[(2S)-4-methyl-2-(phenylcarbamoylamino)pentanoyl]amino]ethyl]-1H-imidazole-4-carboxylic acid |
Molecular weight | 530.629 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 5 |
XlogP | 4.0 |
Synonyms | BDBM50050043 SCHEMBL9110753 5-Methyl-2-{(R)-2-(1-methyl-1H-indol-3-yl)-1-[(S)-4-methyl-2-(3-phenyl-ureido)-pentanoylamino]-ethyl}-1H-imidazole-4-carboxylic acid |
Inchi Key | AZRZDILDBHZBRH-PKTZIBPZSA-N |
Inchi ID | InChI=1S/C29H34N6O4/c1-17(2)14-23(33-29(39)31-20-10-6-5-7-11-20)27(36)32-22(26-30-18(3)25(34-26)28(37)38)15-19-16-35(4)24-13-9-8-12-21(19)24/h5-13,16-17,22-23H,14-15H2,1-4H3,(H,30,34)(H,32,36)(H,37,38)(H2,31,33,39)/t22-,23+/m1/s1 |
PubChem CID | 44385593 |
ChEMBL | CHEMBL367208 |
IUPHAR | N/A |
BindingDB | 50050043 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 7.6 nM | PMID8632420 | BindingDB,ChEMBL |
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