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Name | Prostaglandin D2 receptor 2 |
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Species | Homo sapiens (Human) |
Gene | PTGDR2 |
Synonym | CD294 prostaglandin D2 receptor 2 PGD2 receptor Gpr44 G-protein coupled receptor 44 [ Show all ] |
Disease | Asthma; Chronic obstructive pulmonary disease Asthma Allergy Allergic rhinitis Allergic asthma [ Show all ] |
Length | 395 |
Amino acid sequence | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS |
UniProt | Q9Y5Y4 |
Protein Data Bank | 6d27, 6d26 |
GPCR-HGmod model | Q9Y5Y4 |
3D structure model | This structure is from PDB ID 6d27. |
BioLiP | BL0428440, BL0428439 |
Therapeutic Target Database | T61722 |
ChEMBL | CHEMBL5071 |
IUPHAR | 339 |
DrugBank | BE0003561 |
Name | Ramatroban |
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Molecular formula | C21H21FN2O4S |
IUPAC name | 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid |
Molecular weight | 416.467 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 2.9 |
Synonyms | Tox21_112516 9H-Carbazole-9-propanoic acid, 3-(((4-fluorophenyl)sulfonyl)amino)-1,2,3,4-tetrahydro-, (R)- [3H]ramatroban AN-1137 Bay-u-3405 [ Show all ] |
Inchi Key | LDXDSHIEDAPSSA-OAHLLOKOSA-N |
Inchi ID | InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1 |
PubChem CID | 123879 |
ChEMBL | CHEMBL361812 |
IUPHAR | 1910, 1911 |
BindingDB | 50161746 |
DrugBank | DB13036 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
Activity | >10.0 % | PMID21355602 | ChEMBL |
IC50 | 21.0 nM | PMID19592244 | BindingDB,ChEMBL |
IC50 | 28.0 nM | PMID15715457 | BindingDB,ChEMBL |
IC50 | 29.0 nM | PMID15715457 | BindingDB,ChEMBL |
IC50 | 77.0 nM | PMID21355602 | BindingDB,ChEMBL |
IC50 | 169.0 nM | PMID18318469 | ChEMBL |
IC50 | 195.0 nM | PMID19592244 | BindingDB,ChEMBL |
IC50 | 210.0 nM | PMID19592244 | BindingDB,ChEMBL |
IC50 | 311.0 nM | PMID19608418 | BindingDB,ChEMBL |
IC50 | 461.0 nM | PMID21355602 | BindingDB,ChEMBL |
IC50 | 754.0 nM | PMID19608418 | BindingDB,ChEMBL |
Kd | 7.94328 nM | PMID16256979 | IUPHAR |
Ki | 4.3 nM | PMID15715457 | BindingDB,ChEMBL |
Ki | 5.5 nM | PMID21106375 | BindingDB |
Ki | 39.8107 nM | PMID16256979 | IUPHAR |
Ki | 73.0 nM | PMID19592244 | BindingDB,ChEMBL |
Ki | 137.0 nM | PMID21106375 | BindingDB,ChEMBL |
Ki | 290.0 nM | PMID15745833 | BindingDB,ChEMBL |
Ki | 340.0 nM | PMID15745833 | BindingDB,ChEMBL |
Ratio IC50 | 1.6 - | PMID19592244 | ChEMBL |
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