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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL332414
Molecular formula	C32H39IN4O3
IUPAC name	(E)-5-amino-N-[(2R)-1-[[(2R)-3-(4-iodophenyl)-1-(methylamino)-1-oxopropan-2-yl]-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N,5-dimethylhex-2-enamide
Molecular weight	654.593
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.9
Synonyms	SCHEMBL6319678 BDBM50066820 N-(5-Amino-5-methyl-2-hexenoyl)-N-methyl-3-(2-naphthyl)-D-Ala-N-methyl-4-iodo-D-Phe-NHMe SCHEMBL6319674 (E)-5-Amino-5-methyl-hex-2-enoic acid ((R)-1-{[(R)-2-(4-iodo-phenyl)-1-methylcarbamoyl-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-amide
Inchi Key	LDZXZPPOLPRETN-ODNGPVGPSA-N
Inchi ID	InChI=1S/C32H39IN4O3/c1-32(2,34)18-8-11-29(38)36(4)28(21-23-12-15-24-9-6-7-10-25(24)19-23)31(40)37(5)27(30(39)35-3)20-22-13-16-26(33)17-14-22/h6-17,19,27-28H,18,20-21,34H2,1-5H3,(H,35,39)/b11-8+/t27-,28-/m1/s1
PubChem CID	10675800
ChEMBL	CHEMBL332414
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	20.0 nM	PMID9733496	ChEMBL
Emax	110.0 %	PMID9733496	ChEMBL

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