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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Homo sapiens (Human)
Gene	LHCGR
Synonym	lutropin-choriogonadotropic hormone receptor Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor [ Show all ]
Disease	Heart disease Breast cancer Cancer Myelodysplastic syndrome Female infertility Fertility Leukemia Infertility [ Show all ]
Length	699
Amino acid sequence	MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProt	P22888
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79473
ChEMBL	CHEMBL1854
IUPHAR	N/A
DrugBank	BE0000134

Ligand

Name	MLS000550953
Molecular formula	C24H27N3O6S2
IUPAC name	1,4-dioxane;N-[4-(4-morpholin-4-ylsulfonylphenyl)-1,3-thiazol-2-yl]benzamide
Molecular weight	517.615
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	None
Synonyms	HMS3089A08 SR-01000492986 AC1Q1IBV MolPort-001-801-031 CHEMBL1304031 SMR000145081 SR-01000492986-1 AKOS005614400 N-{4-[4-(morpholin-4-ylsulfonyl)phenyl]-1,3-thiazol-2-yl}benzamide - 1,4-dioxane (1:1) HMS2536E20 SMR001496736 1,4-dioxane; N-{4-[4-(morpholine-4-sulfonyl)phenyl]-1,3-thiazol-2-yl}benzamide MLS002581312 STK820793 N-{4-[4-(Morpholine-4-sulfonyl)-phenyl]-thiazol-2-yl}-benzamide; compound with [1,4]dioxane [ Show all ]
Inchi Key	AZWMCNGECWXGMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19N3O4S2.C4H8O2/c24-19(16-4-2-1-3-5-16)22-20-21-18(14-28-20)15-6-8-17(9-7-15)29(25,26)23-10-12-27-13-11-23;1-2-6-4-3-5-1/h1-9,14H,10-13H2,(H,21,22,24);1-4H2
PubChem CID	9551786
ChEMBL	CHEMBL1304031
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	112202.0 nM	PubChem BioAssay data set	ChEMBL

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