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GPCR

NameC-C chemokine receptor type 6
SpeciesHomo sapiens (Human)
GeneCCR6
SynonymDRY6
G-protein coupled receptor 29
GPR-CY4
GPR29
GPRCY4
[ Show all ]
DiseaseN/A
Length374
Amino acid sequenceMSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM
UniProtP51684
Protein Data BankN/A
GPCR-HGmod modelP51684
3D structure modelThis predicted structure model is from GPCR-EXP P51684.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4423
IUPHARN/A
DrugBankN/A

Ligand

NameMLS000574219
Molecular formulaC18H13ClN2O3
IUPAC name4-chloro-3-(2,5-dioxopyrrol-1-yl)-N-(4-methylphenyl)benzamide
Molecular weight340.763
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.9
Synonyms4-chloro-3-(2,5-dioxo-1-pyrrolyl)-N-(4-methylphenyl)benzamide
MolPort-002-213-003
4-chloro-3-maleimido-N-(p-tolyl)benzamide
HMS2274C17
SR-01000239526-1
[ Show all ]
Inchi KeyACSISLCYYDRVIM-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H13ClN2O3/c1-11-2-5-13(6-3-11)20-18(24)12-4-7-14(19)15(10-12)21-16(22)8-9-17(21)23/h2-10H,1H3,(H,20,24)
PubChem CID885550
ChEMBLCHEMBL1447350
IUPHARN/A
BindingDB66051
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5022000.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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