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Name | C-X-C chemokine receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | CXCR2 |
Synonym | chemokine (C-X-C motif) receptor 2 KC receptor CD128 IL8RB IL-8R2 [ Show all ] |
Disease | Cystic fibrosis; Chronic obstructive pulmonary disease Asthma Cancer Ischemia-reperfusion injury; Lung transplantation; Graft rejection in heart transplantation Fungal infections [ Show all ] |
Length | 360 |
Amino acid sequence | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL |
UniProt | P25025 |
Protein Data Bank | N/A |
GPCR-HGmod model | P25025 |
3D structure model | This predicted structure model is from GPCR-EXP P25025. |
BioLiP | N/A |
Therapeutic Target Database | T56923 |
ChEMBL | CHEMBL2434 |
IUPHAR | 69 |
DrugBank | N/A |
Name | CHEMBL254773 |
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Molecular formula | C23H19BrFN3O3S |
IUPAC name | 1-(benzenesulfonyl)-3-[2-[5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl]ethyl]urea |
Molecular weight | 516.385 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 5.0 |
Synonyms | BDBM50236304 1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)ethyl)-3-(phenylsulfonyl)urea |
Inchi Key | LHYCSAHLAIJJOV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H19BrFN3O3S/c24-16-8-11-21-20(14-16)19(22(27-21)15-6-9-17(25)10-7-15)12-13-26-23(29)28-32(30,31)18-4-2-1-3-5-18/h1-11,14,27H,12-13H2,(H2,26,28,29) |
PubChem CID | 44447946 |
ChEMBL | CHEMBL254773 |
IUPHAR | N/A |
BindingDB | 50236304 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 4.0 nM | PMID18308567 | BindingDB,ChEMBL |
IC50 | 120.0 nM | PMID18308567 | BindingDB,ChEMBL |
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