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GPCR

NameBombesin receptor subtype-3
SpeciesMus musculus (Mouse)
GeneBrs3
Synonymbb3
BB3 receptor
bombesin like receptor 3
bombesin receptor subtype-3
BRS-3
DiseaseN/A for non-human GPCRs
Length399
Amino acid sequenceMSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
UniProtO54798
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075140
IUPHAR40
DrugBankN/A

Ligand

NameCHEMBL1097363
Molecular formulaC24H26N2O3
IUPAC name2-[4-[2-[5-(oxan-4-ylmethyl)-1H-imidazol-2-yl]ethyl]phenyl]benzoic acid
Molecular weight390.483
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.4
SynonymsBDBM50313746
4''-(2-(5-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylic acid
Inchi KeyLJXLTARUYZNXPN-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H26N2O3/c27-24(28)22-4-2-1-3-21(22)19-8-5-17(6-9-19)7-10-23-25-16-20(26-23)15-18-11-13-29-14-12-18/h1-6,8-9,16,18H,7,10-15H2,(H,25,26)(H,27,28)
PubChem CID46881605
ChEMBLCHEMBL1097363
IUPHARN/A
BindingDB50313746
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity106.0 %PMID20167483ChEMBL
EC5023.0 nMPMID20167483BindingDB,ChEMBL

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