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GPCR

NameBeta-2 adrenergic receptor
SpeciesCanis lupus familiaris (Dog)
GeneADRB2
SynonymBeta-2 adrenoceptor
Beta-2 adrenoreceptor
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGQPANRSVFLLAPNGSHAPDQGDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAKETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQLQKIDRSEGRFHAQNLSQVEQDGRSGHGHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSNNSNSRSDYAGEHSGCHLGQEKDSELLCEDPPGTEDRQGTVPSDSVDSQGRNCSTNDSLL
UniProtP54833
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2289
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL41189
Molecular formulaC28H44N2O7
IUPAC name(2S)-1-[2-[2-[2-[2-[(2S)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenoxy]ethoxy]ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol
Molecular weight520.667
Hydrogen bond acceptor9
Hydrogen bond donor4
XlogP2.9
SynonymsN/A
Inchi KeyBALOCXKMXYPXEC-ZEQRLZLVSA-N
Inchi IDInChI=1S/C28H44N2O7/c1-21(2)29-17-23(31)19-36-27-11-7-5-9-25(27)34-15-13-33-14-16-35-26-10-6-8-12-28(26)37-20-24(32)18-30-22(3)4/h5-12,21-24,29-32H,13-20H2,1-4H3/t23-,24-/m0/s1
PubChem CID13208878
ChEMBLCHEMBL41189
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
ED500.15 mg.kg-1PMID6138434ChEMBL

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