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Name | Delta-type opioid receptor |
---|---|
Species | Mus musculus (Mouse) |
Gene | Oprd1 |
Synonym | OP1 MSL-2 K56 DOR-1 DOR [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 372 |
Amino acid sequence | MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTACTPSDGPGGGAAA |
UniProt | P32300 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3222 |
IUPHAR | 317 |
DrugBank | N/A |
Name | CHEMBL163769 |
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Molecular formula | C35H54N8O10 |
IUPAC name | (3S)-3-[[1-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]cyclohexanecarbonyl]amino]-4-[[(2S)-1-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid |
Molecular weight | 746.863 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 10 |
XlogP | -2.1 |
Synonyms | BDBM50049382 (S)-3-[(1-{(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-cyclohexanecarbonyl)-amino]-N-{(S)-1-[(S)-1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid |
Inchi Key | BAPCQJRIYSCLRO-HFQUQZICSA-N |
Inchi ID | InChI=1S/C35H54N8O10/c1-18(2)27(32(51)38-17-25(37)45)42-33(52)28(19(3)4)41-31(50)24(16-26(46)47)40-34(53)35(13-7-6-8-14-35)43-29(48)20(5)39-30(49)23(36)15-21-9-11-22(44)12-10-21/h9-12,18-20,23-24,27-28,44H,6-8,13-17,36H2,1-5H3,(H2,37,45)(H,38,51)(H,39,49)(H,40,53)(H,41,50)(H,42,52)(H,43,48)(H,46,47)/t20-,23-,24-,27-,28-/m0/s1 |
PubChem CID | 44378587 |
ChEMBL | CHEMBL163769 |
IUPHAR | N/A |
BindingDB | 50049382 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 540.0 nM | PMID8576920 | BindingDB,ChEMBL |
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