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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL331093
Molecular formulaC35H44N4O3
IUPAC name(E)-5-amino-N-[(2R)-1-[[(2R)-1-(cyclopropylmethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N,5-dimethylhex-2-enamide
Molecular weight568.762
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP5.0
SynonymsSCHEMBL6318102
(E)-5-Amino-5-methyl-hex-2-enoic acid ((R)-1-{[(R)-1-(cyclopropylmethyl-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-amide
BDBM50066826
SCHEMBL6318096
Inchi KeyLLWWGVBTMDXOJI-BFYFNOAVSA-N
Inchi IDInChI=1S/C35H44N4O3/c1-35(2,36)20-10-15-32(40)38(3)31(23-27-18-19-28-13-8-9-14-29(28)21-27)34(42)39(4)30(22-25-11-6-5-7-12-25)33(41)37-24-26-16-17-26/h5-15,18-19,21,26,30-31H,16-17,20,22-24,36H2,1-4H3,(H,37,41)/b15-10+/t30-,31-/m1/s1
PubChem CID10745618
ChEMBLCHEMBL331093
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC501.8 nMPMID9733496ChEMBL
Emax105.0 %PMID9733496ChEMBL

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