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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	BRD-K67783091-001-04-8 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CCG-36042 4763-EP2272973A1 D00136 4763-EP2295439A1 DSSTox_CID_14150 4763-EP2311824A1 EINECS 200-155-6 AB00052008 gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone AC1Q77Z0 Haldol La Aloperidolo BDBM21398 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone NCGC00015500-10 Haloperidol, United States Pharmacopeia (USP) Reference Standard NCGC00015500-19 HMS1920D03 NCGC00023875-09 HMS3712G12 Serenase (TN) NSC-615296 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 SPBio_002069 Peluces KBio2_006477 SR-01000003076-11 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] Keselan Tox21_110162_1 QTL1_000042 Lopac-H-1512 VU0239704-10 MFCD00051423 Haloperidol (Haldol) NCGC00015500-02 Haloperidol lactate BRN 0331267 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone C-35402 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CHEBI:5613 4763-EP2277876A1 DB00502 4763-EP2305260A1 DTXSID4034150 5-21-02-00377 (Beilstein Handbook Reference) Eukystol (TN) AB00052008_23 gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone AKOS000280660 Aloperidon 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine Biomol-NT_000035 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone Haloperidol [USAN:USP:INN:BAN:JAN] NCGC00015500-13 Halopidol NCGC00023875-04 HMS2095G12 SC-81035 NINDS_000654 HY-14538 Sernel NSC615296 KBio1_000654 Spectrum3_000448 Pernox KBio3_002869 ST50319916 Prestwick2_000115 Lealgin compositum TR-018722 Resin epoxy LS-48311 WLN: T6NTJ A3VR DF& DQ DR DG Halojust MLS001146904 Haloperidol (JP17/USP/INN) NCGC00015500-05 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_000130 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one CAS-52-86-8 4763-EP2272537A2 cMAP_000037 4763-EP2295412A1 Dozic (TN) 4763-EP2311801A1 Einalon S FT-0697842 AC-19691 Haldol Aloperidin (TN) API0002885 177716-59-5 BPBio1_000144 NCGC00015500-08 Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material NCGC00015500-16 Halosten (TN) NCGC00023875-07 HMS3370H11 Serenace (TN) NSC 615296 IDI1_000654 SMR000058303 Oprea1_509923 KBio2_003909 Spectrum_000861 Picroside-III KBioSS_001341 Tocris-0931 Probes1_000255 LNEPOXFFQSENCJ-UHFFFAOYSA- UNII-J6292F8L3D MCULE-3693790133 Haloperido N1910 Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard BRD-K67783091-001-05-5 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one CCG-39111 4763-EP2275420A1 D0D1AL 4763-EP2298731A1 DSSTox_GSID_34150 4763-EP2311837A1 EU-0100583 AB00052008-21 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone AC250 Haldol Solutab Aloperidolo [DCIT] .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone BG0211 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone NCGC00015500-11 Haloperidolum NCGC00016234-01 HMS2089M15 NCGC00254503-01 HMS502A16 Serenelfi NSC-757054 J6292F8L3D SPECTRUM1500325 Peluces (TN) KBio2_007526 SR-01000003076-2 Prestwick0_000115 Keselan (TN) Tox21_300475 R 1625 Lopac0_000583 W-105791 Mixidol Haloperidol (JP15/USP) NCGC00015500-03 Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone Brotopon 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone C01814 4763-EP2269989A1 4763-EP2292614A1 DivK1c_000654 4763-EP2308867A2 Duraperidol 52-86-8 Fortunan AB00052008_24 GTPL86 Aldo AN-41634 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Bioperidolo Haloperidol, 1 NCGC00015500-14 Halopoidol NCGC00023875-05 HMS2234P08 SCHEMBL8264 Novo-Peridol I14-13404 Sigaperidol NSC757054 KBio2_001341 Spectrum4_000570 Pharmakon1600-01500325 KBioGR_000980 STL417208 Prestwick3_000115 Linton Ulcolind S1920 McM-JR-1625 ZINC537822 Halol MolPort-000-883-311 Haloperidol 1.0 mg/ml in Methanol NCGC00015500-06 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_002096 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one CC-16450 4763-EP2272972A1 CS-1971 4763-EP2295413A1 Dozix 4763-EP2311803A1 Einalon S (TN) A0H334 Galoperidol AC1L1G7K Haldol (TN) Aloperidol Apo-Haloperidol BPBio1_001231 NCGC00015500-09 Haloperidol, powder NCGC00015500-17 HMS1568G12 NCGC00023875-08 HMS3657I13 Serenase NSC-170973 IN1474 SPBio_001236 Pekuces KBio2_004958 SR-01000003076 Pms Haloperidol KBioSS_002395 Tox21_110162 Probes2_000296 LNEPOXFFQSENCJ-UHFFFAOYSA-N Vesalium MDMO-PPV NCGC00015500-01 Haloperidol Intensol BRD-K67783091-003-03-6 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CCRIS 1630 4763-EP2277872A1 4763-EP2298776A1 DSSTox_RID_79117 4763-EP2316834A1 Eukystol AB00052008-22 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone ACM1189986591 Halidol Aloperidolo [Italian] .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone BIDD:GT0128 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone Haloperidol [USAN:INN:BAN:JAN] NCGC00015500-12 Haloperidolum [INN-Latin] NCGC00023875-02 HMS2091J09 SC 170973 NCGC00261268-01 HSDB 3093 Sernas NSC170973 KB-79571 Spectrum2_001268 Peridol KBio3_001316 SR-01000003076-8 Prestwick1_000115 L000288 Tox21_500583 R-1625 LP00583 W0039 MLS000028450 Haloperidol (JP15/USP/INN) NCGC00015500-04 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one Brotopon (TN) 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one C21H23ClFNO2 4763-EP2269990A1 CHEMBL54 4763-EP2295061A1 Dozic 4763-EP2308870A2 Duraperidol (TN) 61788-97-4 FT-0669100 AB2000375 H 1512 Aloperidin AOB5645 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- Bioperidolo (TN) Haloperidol, European Pharmacopoeia (EP) Reference Standard NCGC00015500-15 Halosten NCGC00023875-06 HMS3261F08 Serenace NSC 170973 I14-14165 Sigaperidol (TN) Opera_ID_446 KBio2_002390 Spectrum5_000788 Phenolic epoxy resin KBioGR_002390 SW196557-4 Prestwick_250 Linton (TN) Uliolind SBI-0050565.P004 McN-JR-1625 Halopal MRF-0000027 Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard NCGC00015500-07 [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2247.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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