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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	BDBM21398 SC 170973 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone BRD-K67783091-001-04-8 Sernas 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- Spectrum2_001268 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CCG-36042 SR-01000003076-8 4763-EP2272973A1 D00136 Tox21_500583 4763-EP2295439A1 DSSTox_CID_14150 W0039 4763-EP2311824A1 EINECS 200-155-6 AB00052008 gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone AC1Q77Z0 Haldol La Aloperidolo NCGC00015500-14 Halopoidol NCGC00023875-05 HMS2234P08 Novo-Peridol I14-13404 NSC757054 KBio2_001341 Pharmakon1600-01500325 KBioGR_000980 Prestwick3_000115 Linton S1920 McM-JR-1625 Halol MolPort-000-883-311 Haloperidol 1.0 mg/ml in Methanol NCGC00015500-06 Haloperidol, 1 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine Biomol-NT_000035 Serenace 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone BRN 0331267 Sigaperidol (TN) 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone C-35402 Spectrum5_000788 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CHEBI:5613 SW196557-4 4763-EP2277876A1 DB00502 Uliolind 4763-EP2305260A1 DTXSID4034150 5-21-02-00377 (Beilstein Handbook Reference) Eukystol (TN) AB00052008_23 gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone AKOS000280660 Aloperidon Haloperidol, powder NCGC00015500-17 HMS1568G12 NCGC00023875-08 HMS3657I13 NSC-170973 IN1474 Pekuces KBio2_004958 Pms Haloperidol KBioSS_002395 Probes2_000296 LNEPOXFFQSENCJ-UHFFFAOYSA-N MDMO-PPV NCGC00015500-01 Haloperidol Intensol NCGC00015500-09 177716-59-5 BPBio1_000144 Serenase (TN) 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_000130 SPBio_002069 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one CAS-52-86-8 SR-01000003076-11 4763-EP2272537A2 cMAP_000037 Tox21_110162_1 4763-EP2295412A1 Dozic (TN) VU0239704-10 4763-EP2311801A1 Einalon S FT-0697842 AC-19691 Haldol Aloperidin (TN) API0002885 NCGC00015500-12 Haloperidolum [INN-Latin] NCGC00023875-02 HMS2091J09 NCGC00261268-01 HSDB 3093 NSC170973 KB-79571 Peridol KBio3_001316 Prestwick1_000115 L000288 R-1625 LP00583 MLS000028450 Haloperidol (JP15/USP/INN) NCGC00015500-04 Haloperidol [USAN:INN:BAN:JAN] BG0211 SC-81035 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone BRD-K67783091-001-05-5 Sernel 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- Spectrum3_000448 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one CCG-39111 ST50319916 4763-EP2275420A1 D0D1AL TR-018722 4763-EP2298731A1 DSSTox_GSID_34150 WLN: T6NTJ A3VR DF& DQ DR DG 4763-EP2311837A1 EU-0100583 AB00052008-21 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone AC250 Haldol Solutab Aloperidolo [DCIT] .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone NCGC00015500-15 Halosten NCGC00023875-06 HMS3261F08 NSC 170973 I14-14165 Opera_ID_446 KBio2_002390 Phenolic epoxy resin KBioGR_002390 Prestwick_250 Linton (TN) SBI-0050565.P004 McN-JR-1625 Halopal MRF-0000027 Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard NCGC00015500-07 Haloperidol, European Pharmacopoeia (EP) Reference Standard 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Bioperidolo Serenace (TN) 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone Brotopon SMR000058303 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone C01814 Spectrum_000861 4763-EP2269989A1 Tocris-0931 4763-EP2292614A1 DivK1c_000654 UNII-J6292F8L3D 4763-EP2308867A2 Duraperidol 52-86-8 Fortunan AB00052008_24 GTPL86 Aldo AN-41634 Haloperidol, United States Pharmacopeia (USP) Reference Standard NCGC00015500-19 HMS1920D03 NCGC00023875-09 HMS3712G12 NSC-615296 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 Peluces KBio2_006477 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] Keselan QTL1_000042 Lopac-H-1512 MFCD00051423 Haloperidol (Haldol) NCGC00015500-02 Haloperidol lactate NCGC00015500-10 Apo-Haloperidol BPBio1_001231 Serenelfi 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_002096 SPECTRUM1500325 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one CC-16450 SR-01000003076-2 4763-EP2272972A1 CS-1971 Tox21_300475 4763-EP2295413A1 Dozix W-105791 4763-EP2311803A1 Einalon S (TN) A0H334 Galoperidol AC1L1G7K Haldol (TN) Aloperidol NCGC00015500-13 Halopidol NCGC00023875-04 HMS2095G12 NINDS_000654 HY-14538 NSC615296 KBio1_000654 Pernox KBio3_002869 Prestwick2_000115 Lealgin compositum Resin epoxy LS-48311 Halojust MLS001146904 Haloperidol (JP17/USP/INN) NCGC00015500-05 Haloperidol [USAN:USP:INN:BAN:JAN] BIDD:GT0128 SCHEMBL8264 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone BRD-K67783091-003-03-6 Sigaperidol 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- Spectrum4_000570 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone CCRIS 1630 STL417208 4763-EP2277872A1 Ulcolind 4763-EP2298776A1 DSSTox_RID_79117 ZINC537822 4763-EP2316834A1 Eukystol AB00052008-22 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone ACM1189986591 Halidol Aloperidolo [Italian] .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone NCGC00015500-16 Halosten (TN) NCGC00023875-07 HMS3370H11 NSC 615296 IDI1_000654 Oprea1_509923 KBio2_003909 Picroside-III KBioSS_001341 Probes1_000255 LNEPOXFFQSENCJ-UHFFFAOYSA- MCULE-3693790133 Haloperido N1910 Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard NCGC00015500-08 Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- Bioperidolo (TN) Serenase 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one Brotopon (TN) SPBio_001236 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one C21H23ClFNO2 SR-01000003076 4763-EP2269990A1 CHEMBL54 Tox21_110162 4763-EP2295061A1 Dozic Vesalium 4763-EP2308870A2 Duraperidol (TN) 61788-97-4 FT-0669100 AB2000375 H 1512 Aloperidin AOB5645 Haloperidolum NCGC00016234-01 HMS2089M15 NCGC00254503-01 HMS502A16 NSC-757054 J6292F8L3D Peluces (TN) KBio2_007526 Prestwick0_000115 Keselan (TN) R 1625 Lopac0_000583 Mixidol Haloperidol (JP15/USP) NCGC00015500-03 Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material NCGC00015500-11 [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID10743959, PMID1676427	BindingDB,ChEMBL
IC50	1993.0 nM	PMID12361392	BindingDB,ChEMBL
IC50	3200.0 nM	PMID7783131	BindingDB,ChEMBL
IC50	6210.0 nM	PMID1672156	BindingDB,ChEMBL
IC50	7000.0 nM	PMID7914539, PMID8568802, PMID8676355	BindingDB,ChEMBL
IC50	7079.0 nM	PMID8831770, PMID7914536	BindingDB,ChEMBL
IC50	7079.0 nM	PMID7914536	BindingDB
Ki	<500.0 nM	PMID10464021	BindingDB,ChEMBL
Ki	<1000.0 nM	PMID9622541, PMID7909336	BindingDB,ChEMBL
Ki	401.0 nM	PMID1346653, PMID7473548, PMID7473547	BindingDB,ChEMBL
Ki	1698.24 nM	PMID17300168	ChEMBL
Ki	1800.0 nM	, Bioorg. Med. Chem. Lett., (1995) 5:12:1245, PMID19072656	BindingDB,ChEMBL
Ki	1900.0 nM	PMID8709107	BindingDB,ChEMBL
Ki	2390.0 nM	PMID10649982	BindingDB,ChEMBL
Ki	2500.0 nM	PMID8996185	BindingDB
Ki	2600.0 nM	PMID9430133	BindingDB
Ki	3080.0 nM	PMID8935801	BindingDB
Ki	3548.13 nM	PMID6225026	BindingDB
Ki	4168.69 nM	PMID6225026	BindingDB
Ki	5750.0 nM	PMID1353116	BindingDB,ChEMBL
Ki	7930.0 nM	PMID8822531	BindingDB
Ki	8400.0 nM	PMID9876110	BindingDB,ChEMBL
Ki	9110.0 nM	PMID2869639	BindingDB