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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	NCGC00015500-08 4763-EP2292614A1 Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material DivK1c_000654 NCGC00015500-16 4763-EP2308867A2 Halosten (TN) Duraperidol NCGC00023875-07 52-86-8 HMS3370H11 Fortunan NSC 615296 AB00052008_24 IDI1_000654 GTPL86 Oprea1_509923 Aldo KBio2_003909 Picroside-III AN-41634 KBioSS_001341 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Probes1_000255 Bioperidolo LNEPOXFFQSENCJ-UHFFFAOYSA- 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone Brotopon MCULE-3693790133 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone Haloperido C01814 N1910 4763-EP2269989A1 Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard SR-01000003076-8 Tox21_500583 W0039 SC 170973 Sernas Spectrum2_001268 Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material CS-1971 NCGC00015500-11 4763-EP2295413A1 Haloperidolum Dozix NCGC00016234-01 4763-EP2311803A1 HMS2089M15 Einalon S (TN) NCGC00254503-01 A0H334 HMS502A16 Galoperidol NSC-757054 AC1L1G7K J6292F8L3D Haldol (TN) Peluces (TN) Aloperidol KBio2_007526 Prestwick0_000115 Apo-Haloperidol Keselan (TN) R 1625 BPBio1_001231 Lopac0_000583 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_002096 Mixidol 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one Haloperidol (JP15/USP) CC-16450 NCGC00015500-03 4763-EP2272972A1 Spectrum5_000788 SW196557-4 Uliolind Serenace Sigaperidol (TN) 4763-EP2277872A1 Haloperidol, 1 NCGC00015500-14 4763-EP2298776A1 Halopoidol DSSTox_RID_79117 NCGC00023875-05 4763-EP2316834A1 HMS2234P08 Eukystol Novo-Peridol AB00052008-22 I14-13404 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone NSC757054 ACM1189986591 KBio2_001341 Halidol Pharmakon1600-01500325 Aloperidolo [Italian] KBioGR_000980 .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone Prestwick3_000115 BIDD:GT0128 Linton 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone S1920 BRD-K67783091-003-03-6 McM-JR-1625 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone Halol Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- MolPort-000-883-311 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Haloperidol 1.0 mg/ml in Methanol CCRIS 1630 NCGC00015500-06 SR-01000003076-11 Tox21_110162_1 VU0239704-10 Serenase (TN) SPBio_002069 NCGC00015500-09 4763-EP2295061A1 Haloperidol, powder Dozic NCGC00015500-17 4763-EP2308870A2 HMS1568G12 Duraperidol (TN) NCGC00023875-08 61788-97-4 HMS3657I13 FT-0669100 NSC-170973 AB2000375 IN1474 H 1512 Pekuces Aloperidin KBio2_004958 Pms Haloperidol AOB5645 KBioSS_002395 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- Probes2_000296 Bioperidolo (TN) LNEPOXFFQSENCJ-UHFFFAOYSA-N 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one Brotopon (TN) MDMO-PPV 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one C21H23ClFNO2 NCGC00015500-01 4763-EP2269990A1 Haloperidol Intensol CHEMBL54 ST50319916 TR-018722 WLN: T6NTJ A3VR DF& DQ DR DG SC-81035 Sernel Spectrum3_000448 Haloperidol [USAN:INN:BAN:JAN] D00136 NCGC00015500-12 4763-EP2295439A1 Haloperidolum [INN-Latin] DSSTox_CID_14150 NCGC00023875-02 4763-EP2311824A1 HMS2091J09 EINECS 200-155-6 NCGC00261268-01 AB00052008 HSDB 3093 gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone NSC170973 AC1Q77Z0 KB-79571 Haldol La Peridol Aloperidolo KBio3_001316 Prestwick1_000115 BDBM21398 L000288 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone R-1625 BRD-K67783091-001-04-8 LP00583 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- MLS000028450 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Haloperidol (JP15/USP/INN) CCG-36042 NCGC00015500-04 4763-EP2272973A1 Spectrum_000861 Tocris-0931 UNII-J6292F8L3D Serenace (TN) SMR000058303 NCGC00015500-07 4763-EP2277876A1 Haloperidol, European Pharmacopoeia (EP) Reference Standard DB00502 NCGC00015500-15 4763-EP2305260A1 Halosten DTXSID4034150 NCGC00023875-06 5-21-02-00377 (Beilstein Handbook Reference) HMS3261F08 Eukystol (TN) NSC 170973 AB00052008_23 I14-14165 gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone Opera_ID_446 AKOS000280660 KBio2_002390 Phenolic epoxy resin Aloperidon KBioGR_002390 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine Prestwick_250 Biomol-NT_000035 Linton (TN) 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone SBI-0050565.P004 BRN 0331267 McN-JR-1625 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone Halopal C-35402 MRF-0000027 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard CHEBI:5613 SR-01000003076-2 Tox21_300475 W-105791 Serenelfi SPECTRUM1500325 cMAP_000037 NCGC00015500-10 4763-EP2295412A1 Haloperidol, United States Pharmacopeia (USP) Reference Standard Dozic (TN) NCGC00015500-19 4763-EP2311801A1 HMS1920D03 Einalon S NCGC00023875-09 HMS3712G12 FT-0697842 NSC-615296 AC-19691 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 Haldol Peluces Aloperidin (TN) KBio2_006477 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] API0002885 Keselan 177716-59-5 QTL1_000042 BPBio1_000144 Lopac-H-1512 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone BSPBio_000130 MFCD00051423 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one Haloperidol (Haldol) CAS-52-86-8 NCGC00015500-02 4763-EP2272537A2 Haloperidol lactate STL417208 Ulcolind ZINC537822 SCHEMBL8264 Sigaperidol Spectrum4_000570 Haloperidol [USAN:USP:INN:BAN:JAN] D0D1AL NCGC00015500-13 4763-EP2298731A1 Halopidol DSSTox_GSID_34150 NCGC00023875-04 4763-EP2311837A1 HMS2095G12 EU-0100583 NINDS_000654 AB00052008-21 HY-14538 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone NSC615296 AC250 KBio1_000654 Haldol Solutab Pernox Aloperidolo [DCIT] KBio3_002869 .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone Prestwick2_000115 BG0211 Lealgin compositum 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone Resin epoxy BRD-K67783091-001-05-5 LS-48311 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Halojust Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- MLS001146904 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one Haloperidol (JP17/USP/INN) CCG-39111 NCGC00015500-05 4763-EP2275420A1 SR-01000003076 Tox21_110162 Vesalium Serenase SPBio_001236 [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID9406603, PMID10377229	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID9225287, PMID9686407	BindingDB
Ki	1500.0 nM	PMID9430133	BindingDB
Ki	2320.0 nM	PMID1347569	BindingDB
Ki	2511.88 nM	PMID7908055	BindingDB
Ki	4600.0 nM	PMID3139864	BindingDB
Ki	4700.0 nM	PMID25070422	BindingDB,ChEMBL

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