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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	Serenase (TN) SPBio_002069 SR-01000003076-11 Tox21_110162_1 VU0239704-10 GTPL86 Probes2_000296 Aldo LNEPOXFFQSENCJ-UHFFFAOYSA-N AN-41634 MDMO-PPV 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Bioperidolo NCGC00015500-01 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone Haloperidol Intensol Brotopon NCGC00015500-09 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone Haloperidol, powder C01814 NCGC00015500-17 4763-EP2269989A1 HMS1568G12 NCGC00023875-08 4763-EP2292614A1 HMS3657I13 DivK1c_000654 NSC-170973 4763-EP2308867A2 IN1474 Duraperidol Pekuces 52-86-8 KBio2_004958 Fortunan Pms Haloperidol AB00052008_24 KBioSS_002395 SC-81035 Sernel Spectrum3_000448 ST50319916 TR-018722 WLN: T6NTJ A3VR DF& DQ DR DG Haldol (TN) R-1625 Aloperidol LP00583 Apo-Haloperidol MLS000028450 Haloperidol (JP15/USP/INN) BPBio1_001231 NCGC00015500-04 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone Haloperidol [USAN:INN:BAN:JAN] BSPBio_002096 NCGC00015500-12 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one Haloperidolum [INN-Latin] CC-16450 NCGC00023875-02 4763-EP2272972A1 HMS2091J09 CS-1971 NCGC00261268-01 4763-EP2295413A1 HSDB 3093 Dozix NSC170973 4763-EP2311803A1 KB-79571 Einalon S (TN) Peridol A0H334 KBio3_001316 Galoperidol Prestwick1_000115 AC1L1G7K L000288 Serenace (TN) SMR000058303 Spectrum_000861 Tocris-0931 UNII-J6292F8L3D ACM1189986591 Linton (TN) Halidol SBI-0050565.P004 Aloperidolo [Italian] McN-JR-1625 .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone Halopal BIDD:GT0128 MRF-0000027 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard BRD-K67783091-003-03-6 NCGC00015500-07 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone Haloperidol, European Pharmacopoeia (EP) Reference Standard Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- NCGC00015500-15 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Halosten CCRIS 1630 NCGC00023875-06 4763-EP2277872A1 HMS3261F08 NSC 170973 4763-EP2298776A1 I14-14165 DSSTox_RID_79117 Opera_ID_446 4763-EP2316834A1 KBio2_002390 Eukystol Phenolic epoxy resin AB00052008-22 KBioGR_002390 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone Prestwick_250 Serenelfi SPECTRUM1500325 SR-01000003076-2 Tox21_300475 W-105791 H 1512 QTL1_000042 Aloperidin Lopac-H-1512 AOB5645 MFCD00051423 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- Haloperidol (Haldol) Bioperidolo (TN) NCGC00015500-02 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one Haloperidol lactate Brotopon (TN) NCGC00015500-10 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one Haloperidol, United States Pharmacopeia (USP) Reference Standard C21H23ClFNO2 NCGC00015500-19 4763-EP2269990A1 HMS1920D03 CHEMBL54 NCGC00023875-09 4763-EP2295061A1 HMS3712G12 Dozic NSC-615296 4763-EP2308870A2 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 Duraperidol (TN) Peluces 61788-97-4 KBio2_006477 FT-0669100 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] AB2000375 Keselan SCHEMBL8264 Sigaperidol Spectrum4_000570 STL417208 Ulcolind ZINC537822 AC1Q77Z0 Lealgin compositum Haldol La Resin epoxy Aloperidolo LS-48311 Halojust BDBM21398 MLS001146904 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone Haloperidol (JP17/USP/INN) BRD-K67783091-001-04-8 NCGC00015500-05 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone Haloperidol [USAN:USP:INN:BAN:JAN] Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- NCGC00015500-13 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Halopidol CCG-36042 NCGC00023875-04 4763-EP2272973A1 HMS2095G12 D00136 NINDS_000654 4763-EP2295439A1 HY-14538 DSSTox_CID_14150 NSC615296 4763-EP2311824A1 KBio1_000654 EINECS 200-155-6 Pernox AB00052008 KBio3_002869 gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone Prestwick2_000115 Serenase SPBio_001236 SR-01000003076 Tox21_110162 Vesalium AKOS000280660 LNEPOXFFQSENCJ-UHFFFAOYSA- Aloperidon MCULE-3693790133 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine Haloperido Biomol-NT_000035 N1910 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard BRN 0331267 NCGC00015500-08 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material C-35402 NCGC00015500-16 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone Halosten (TN) CHEBI:5613 NCGC00023875-07 4763-EP2277876A1 HMS3370H11 DB00502 NSC 615296 4763-EP2305260A1 IDI1_000654 DTXSID4034150 Oprea1_509923 5-21-02-00377 (Beilstein Handbook Reference) KBio2_003909 Eukystol (TN) Picroside-III AB00052008_23 KBioSS_001341 gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone Probes1_000255 SC 170973 Sernas Spectrum2_001268 SR-01000003076-8 Tox21_500583 W0039 Haldol R 1625 Aloperidin (TN) Lopac0_000583 API0002885 Mixidol 177716-59-5 Haloperidol (JP15/USP) BPBio1_000144 NCGC00015500-03 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material BSPBio_000130 NCGC00015500-11 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one Haloperidolum CAS-52-86-8 NCGC00016234-01 4763-EP2272537A2 HMS2089M15 cMAP_000037 NCGC00254503-01 4763-EP2295412A1 HMS502A16 Dozic (TN) NSC-757054 4763-EP2311801A1 J6292F8L3D Einalon S Peluces (TN) KBio2_007526 FT-0697842 Prestwick0_000115 AC-19691 Keselan (TN) Serenace Sigaperidol (TN) Spectrum5_000788 SW196557-4 Uliolind AC250 Linton Haldol Solutab S1920 Aloperidolo [DCIT] McM-JR-1625 .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone Halol BG0211 MolPort-000-883-311 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone Haloperidol 1.0 mg/ml in Methanol BRD-K67783091-001-05-5 NCGC00015500-06 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Haloperidol, 1 Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- NCGC00015500-14 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one Halopoidol CCG-39111 NCGC00023875-05 4763-EP2275420A1 HMS2234P08 D0D1AL Novo-Peridol 4763-EP2298731A1 I14-13404 DSSTox_GSID_34150 NSC757054 4763-EP2311837A1 KBio2_001341 EU-0100583 Pharmakon1600-01500325 AB00052008-21 KBioGR_000980 gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone Prestwick3_000115 [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	3683.0 nM	PMID8997630	BindingDB
Ki	5000.0 nM	PMID7908055, PMID9430133, PMID8935801	BindingDB

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