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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Bos taurus (Bovine)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
UniProt	Q75Z89
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3446
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	haloperidol
Molecular formula	C21H23ClFNO2
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular weight	375.868
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.2
Synonyms	NSC-170973 DSSTox_RID_79117 IN1474 4763-EP2316834A1 Pekuces Eukystol KBio2_004958 Serenase (TN) AB00052008-22 Pms Haloperidol gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone KBioSS_002395 SPBio_002069 ACM1189986591 Probes2_000296 Halidol LNEPOXFFQSENCJ-UHFFFAOYSA-N SR-01000003076-11 Aloperidolo [Italian] .gamma.-[4-(p-Chlorphenyl)-4-hydroxpiperidino]-p-fluorbutyrophenone MDMO-PPV Tox21_110162_1 BIDD:GT0128 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone NCGC00015500-01 VU0239704-10 BRD-K67783091-003-03-6 Haloperidol Intensol 4-[4-(4-Chlorophenyl)-4-hydroxy- 1-piperidinyl]-1-(4-fluorophenyl)- 1-butanone NCGC00015500-09 Butyrophenone, 4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- Haloperidol, powder 4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone NCGC00015500-17 CCRIS 1630 HMS1568G12 4763-EP2277872A1 NCGC00023875-08 HMS3657I13 4763-EP2298776A1 HSDB 3093 4763-EP2308870A2 NSC170973 Duraperidol (TN) KB-79571 SC-81035 61788-97-4 Peridol FT-0669100 KBio3_001316 Sernel AB2000375 Prestwick1_000115 H 1512 L000288 Spectrum3_000448 Aloperidin R-1625 LP00583 ST50319916 AOB5645 1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)- MLS000028450 TR-018722 Bioperidolo (TN) Haloperidol (JP15/USP/INN) 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one NCGC00015500-04 WLN: T6NTJ A3VR DF& DQ DR DG Brotopon (TN) Haloperidol [USAN:INN:BAN:JAN] 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one NCGC00015500-12 C21H23ClFNO2 Haloperidolum [INN-Latin] 4763-EP2269990A1 NCGC00023875-02 CHEMBL54 HMS2091J09 4763-EP2295061A1 NCGC00261268-01 Dozic DSSTox_CID_14150 I14-14165 4763-EP2311824A1 Opera_ID_446 EINECS 200-155-6 KBio2_002390 Serenace (TN) AB00052008 Phenolic epoxy resin gamma-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone KBioGR_002390 SMR000058303 AC1Q77Z0 Prestwick_250 Haldol La Linton (TN) Spectrum_000861 Aloperidolo SBI-0050565.P004 McN-JR-1625 Tocris-0931 BDBM21398 Halopal 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone MRF-0000027 UNII-J6292F8L3D BRD-K67783091-001-04-8 Haloperidol for peak identification, European Pharmacopoeia (EP) Reference Standard 4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone NCGC00015500-07 Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)- Haloperidol, European Pharmacopoeia (EP) Reference Standard 4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone NCGC00015500-15 CCG-36042 Halosten 4763-EP2272973A1 NCGC00023875-06 D00136 HMS3261F08 4763-EP2295439A1 NSC 170973 4763-EP2305260A1 NSC-615296 DTXSID4034150 InChI=1/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 5-21-02-00377 (Beilstein Handbook Reference) Peluces Eukystol (TN) KBio2_006477 Serenelfi AB00052008_23 Poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] gamma-[4-(p-chlorophenyl)-4-hydroxypiperidino]-p-fluorobutyrophenone Keselan SPECTRUM1500325 AKOS000280660 QTL1_000042 Lopac-H-1512 SR-01000003076-2 Aloperidon 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine MFCD00051423 Tox21_300475 Biomol-NT_000035 Haloperidol (Haldol) 4'-Fluoro-4-[4-hydroxy-4-(4'-chlorophenyl)piperidino]butyrophenone NCGC00015500-02 W-105791 BRN 0331267 Haloperidol lactate 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl) -1-butanone NCGC00015500-10 C-35402 Haloperidol, United States Pharmacopeia (USP) Reference Standard 4-[4-(para-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone NCGC00015500-19 CHEBI:5613 HMS1920D03 4763-EP2277876A1 NCGC00023875-09 DB00502 HMS3712G12 HY-14538 4763-EP2311801A1 NSC615296 Einalon S KBio1_000654 SCHEMBL8264 Pernox FT-0697842 KBio3_002869 Sigaperidol AC-19691 Prestwick2_000115 Haldol Lealgin compositum Spectrum4_000570 Aloperidin (TN) Resin epoxy LS-48311 STL417208 API0002885 Halojust 177716-59-5 MLS001146904 Ulcolind BPBio1_000144 Haloperidol (JP17/USP/INN) 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone NCGC00015500-05 ZINC537822 BSPBio_000130 Haloperidol [USAN:USP:INN:BAN:JAN] 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)butan-1-one NCGC00015500-13 CAS-52-86-8 Halopidol 4763-EP2272537A2 NCGC00023875-04 cMAP_000037 HMS2095G12 4763-EP2295412A1 NINDS_000654 Dozic (TN) NSC 615296 DSSTox_GSID_34150 IDI1_000654 4763-EP2311837A1 Oprea1_509923 EU-0100583 KBio2_003909 Serenase AB00052008-21 Picroside-III gamma-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone KBioSS_001341 SPBio_001236 AC250 Probes1_000255 Haldol Solutab LNEPOXFFQSENCJ-UHFFFAOYSA- SR-01000003076 Aloperidolo [DCIT] .gamma.-(4-(p-Chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone MCULE-3693790133 Tox21_110162 BG0211 Haloperido 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone N1910 Vesalium BRD-K67783091-001-05-5 Haloperidol for system suitability, European Pharmacopoeia (EP) Reference Standard 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) NCGC00015500-08 Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro- Haloperidol, Pharmaceutical Secondary Standard; Certified Reference Material 4-[4-(4-chlorophenyl)-4-hydroxypiperidyl]-1-(4-fluorophenyl)butan-1-one NCGC00015500-16 CCG-39111 Halosten (TN) 4763-EP2275420A1 NCGC00023875-07 D0D1AL HMS3370H11 4763-EP2298731A1 4763-EP2308867A2 NSC-757054 Duraperidol J6292F8L3D SC 170973 52-86-8 Peluces (TN) Fortunan KBio2_007526 Sernas AB00052008_24 Prestwick0_000115 GTPL86 Keselan (TN) Spectrum2_001268 Aldo R 1625 Lopac0_000583 SR-01000003076-8 AN-41634 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)- Mixidol Tox21_500583 Bioperidolo Haloperidol (JP15/USP) 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone NCGC00015500-03 W0039 Brotopon Haloperidol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone NCGC00015500-11 C01814 Haloperidolum 4763-EP2269989A1 NCGC00016234-01 HMS2089M15 4763-EP2292614A1 NCGC00254503-01 DivK1c_000654 HMS502A16 Dozix I14-13404 4763-EP2311803A1 NSC757054 Einalon S (TN) KBio2_001341 Serenace A0H334 Pharmakon1600-01500325 Galoperidol KBioGR_000980 Sigaperidol (TN) AC1L1G7K Prestwick3_000115 Haldol (TN) Linton Spectrum5_000788 Aloperidol S1920 McM-JR-1625 SW196557-4 Apo-Haloperidol Halol MolPort-000-883-311 Uliolind BPBio1_001231 Haloperidol 1.0 mg/ml in Methanol 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone NCGC00015500-06 BSPBio_002096 Haloperidol, 1 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one NCGC00015500-14 CC-16450 Halopoidol 4763-EP2272972A1 NCGC00023875-05 CS-1971 HMS2234P08 4763-EP2295413A1 Novo-Peridol [ Show all ]
Inchi Key	LNEPOXFFQSENCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
PubChem CID	3559
ChEMBL	CHEMBL54
IUPHAR	86
BindingDB	21398
DrugBank	DB00502
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	30.0 nM	PMID9622542	BindingDB,ChEMBL
Ki	106.0 nM	Hartig et al., PMID1985	PDSP

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