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GPCR

NameProstaglandin D2 receptor 2
SpeciesMus musculus (Mouse)
GenePtgdr2
SynonymPGD2 receptor
Gpr44
G-protein coupled receptor 44
G protein-coupled receptor 44
DP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length382
Amino acid sequenceMANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProtQ9Z2J6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2291
IUPHAR339
DrugBankN/A

Ligand

NameCHEMBL1917389
Molecular formulaC16H10Cl2O3
IUPAC name2-[4-chloro-2-[2-(3-chlorophenyl)ethynyl]phenoxy]acetic acid
Molecular weight321.153
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.8
SynonymsZINC73161492
BDBM50356646
LROYLZZPNSRGAA-UHFFFAOYSA-N
{4-chloro-2-[(3-chlorophenyl)ethynyl]phenoxy}acetic acid
SCHEMBL1368182
Inchi KeyLROYLZZPNSRGAA-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H10Cl2O3/c17-13-3-1-2-11(8-13)4-5-12-9-14(18)6-7-15(12)21-10-16(19)20/h1-3,6-9H,10H2,(H,19,20)
PubChem CID46865762
ChEMBLCHEMBL1917389
IUPHARN/A
BindingDB50356646
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki37.0 nMPMID21916510BindingDB
Ki37.4 nMPMID21916510ChEMBL

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