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Name | Somatostatin receptor type 2 |
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Species | Rattus norvegicus (Rat) |
Gene | Sstr2 |
Synonym | somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 369 |
Amino acid sequence | MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI |
UniProt | P30680 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2978 |
IUPHAR | 356 |
DrugBank | N/A |
Name | CHEMBL251111 |
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Molecular formula | C28H34N4O3 |
IUPAC name | 3-[1-[(3R,4aR,10aR)-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline-3-carbonyl]piperidin-4-yl]-1H-benzimidazol-2-one |
Molecular weight | 474.605 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 3.2 |
Synonyms | BDBM50423333 |
Inchi Key | LTEYDHXSVIXJGA-UMEGOILYSA-N |
Inchi ID | InChI=1S/C28H34N4O3/c1-30-17-20(14-19-15-22-18(16-25(19)30)6-5-9-26(22)35-2)27(33)31-12-10-21(11-13-31)32-24-8-4-3-7-23(24)29-28(32)34/h3-9,19-21,25H,10-17H2,1-2H3,(H,29,34)/t19-,20-,25-/m1/s1 |
PubChem CID | 44441928 |
ChEMBL | CHEMBL251111 |
IUPHAR | N/A |
BindingDB | 50423333 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 2041.74 nM | PMID17512199 | ChEMBL |
Kd | 2042.0 nM | PMID17512199 | BindingDB |
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