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GLASS

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GPCR

Name	G-protein coupled receptor 52
Species	Homo sapiens (Human)
Gene	GPR52
Synonym	GPR52
Disease	N/A
Length	361
Amino acid sequence	MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI
UniProt	Q9Y2T5
Protein Data Bank	N/A
GPCR-HGmod model	Q9Y2T5
3D structure model	This predicted structure model is from GPCR-EXP Q9Y2T5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3297639
IUPHAR	108
DrugBank	N/A

Ligand

Name	CHEMBL3299018
Molecular formula	C22H25N3O3
IUPAC name	N-[2-(3,4-dimethoxy-2-methylphenyl)ethyl]-4-(4-methoxyphenyl)pyrimidin-2-amine
Molecular weight	379.46
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.4
Synonyms	BDBM50022152
Inchi Key	LVPGUBUWHFHLFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N3O3/c1-15-16(7-10-20(27-3)21(15)28-4)11-13-23-22-24-14-12-19(25-22)17-5-8-18(26-2)9-6-17/h5-10,12,14H,11,13H2,1-4H3,(H,23,24,25)
PubChem CID	90645440
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50022152
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	>10000.0 nM	PMID24884590	BindingDB

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