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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neurotensin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Ntsr2
Synonym	NTRL NTR2 NT2R NT-R-2 neurotensin receptor type 2 levocabastine-sensitive neurotensin receptor High-affinity levocabastine-sensitive neurotensin receptor NTS2 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	416
Amino acid sequence	METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
UniProt	Q63384
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5106
IUPHAR	310
DrugBank	N/A

Ligand

Name	SR142948A
Molecular formula	C39H51N5O6
IUPAC name	2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methylcarbamoyl]-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid
Molecular weight	685.866
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	3.6
Synonyms	BDBM50440738 D0OJ7S MFCD03106502 SR 142948 hydrochloride 2-[[5-(2,6-dimethoxyphenyl)-1-[4-(3-dimethylaminopropyl-methylcarbamoyl)-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid CAS_184162-64-9 HMS3268L04 NCGC00167732-01 SR-142948 AKOS024457043 L015605 SCHEMBL7558783 ZINC3928282 2-[5-(2,6-dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid BDBM85050 DTXSID50415529 MLS-0437457.0001 SR 142948A 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methylcarbamoyl]-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid CHEBI:93589 J-011801 PDSP1_001736 SR-142948A 184162-21-8 B7012 CHEMBL3040381 LWULHXVBLMWCHO-UHFFFAOYSA-N SR 142948 2-[[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole3-carbonyl]amino] adamantane-2-carboxylic acid hydrochloride BRD-K91243525-001-01-5 GTPL1580 MolPort-023-276-389 SR-142,948 2-[[[5-(2,6-DIMETHOXYPHENYL)-1-[4-[[[3-(DIMETHYLAMINO)PROPYL]METHYLAMINO]CARBONYL]-2-(1-METHYLETHYL)PHENYL]-1H-PYRAZOL-3-YL]CARBONYL]AMINO]-TRICYCLO[3.3.1.13,7]DECANE-2-CARBOXYLIC ACID AC1NSKNX CHEMBL2431105 KB-275336 PDSP2_001719 184162-64-9 [ Show all ]
Inchi Key	LWULHXVBLMWCHO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C39H51N5O6/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48)
PubChem CID	5311451
ChEMBL	CHEMBL3040381
IUPHAR	1580
BindingDB	50440738, 85050
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	18.0 nM	PMID25499438	BindingDB,ChEMBL
EC50	20.0 nM	PMID24856674	BindingDB,ChEMBL
EC50	22.0 nM	PMID25157640	BindingDB,ChEMBL
Emax	100.0 %	PMID24856674	ChEMBL
Ki	5.8 nM	PMID25157640	BindingDB,ChEMBL
Ki	6.0 nM	PMID24856674	ChEMBL
Ki	6.0 nM	PMID24856674	BindingDB
Ki	7.0 nM	PMID25499438	ChEMBL
Ki	7.0 nM	PMID25499438	BindingDB

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