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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Homo sapiens (Human)
Gene	HTR2B
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B 5-HT2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Show all ]
Disease	Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease Congestive heart failure Pulmonary arterial hypertension [ Show all ]
Length	481
Amino acid sequence	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
UniProt	P41595
Protein Data Bank	5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0
GPCR-HGmod model	P41595
3D structure model	This structure is from PDB ID 5tud.
BioLiP	BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287
Therapeutic Target Database	T31204
ChEMBL	CHEMBL1833
IUPHAR	7
DrugBank	BE0000393

Ligand

Name	alpha-methyl-5-HT
Molecular formula	C11H14N2O
IUPAC name	3-(2-aminopropyl)-1H-indol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.6
Synonyms	Alpha Methyl 5 Hydroxytryptamine BRD-A17745711-103-01-0 GTPL152 NCGC00024651-02 LYPCGXKCQDYTFV-UHFFFAOYSA-N PDSP1_001679 AC1L1CXO Biomol-NT_000085 D09OYA NCGC00015629-04 SCHEMBL396996 alpha-M-5-HT CCG-204907 L001159 NCGC00024651-03 3-(2-aminopropyl)-1H-indol-5-ol alpha-Methylserotonin CHEMBL275854 MB03476 PDSP2_001101 AKOS022643479 BPBio1_001083 FT-0645249 NCGC00015629-05 alpha-Me-5-HT CHEBI:48295 Lopac0_000823 PDSP1_001117 BDBM50014945 CTK6A6964 NCGC00015629-03 PDSP2_001662 [ Show all ]
Inchi Key	LYPCGXKCQDYTFV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11/h2-3,5-7,13-14H,4,12H2,1H3
PubChem CID	2107
ChEMBL	CHEMBL275854
IUPHAR	152
BindingDB	50014945
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.99526 nM	PMID10498829	PDSP
Ki	5.01187 - 12.5893 nM	PMID15322733, PMID8078486, PMID15466450	IUPHAR
Ki	6.91831 nM	PMID15322733	PDSP
Ki	11.5 nM	PMID8632342	PDSP
Ki	11.9 nM	PMID8078486	PDSP
Ki	13.0 nM	PMID16392816, PMID12954071	BindingDB,ChEMBL

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