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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL164586
Molecular formula	C29H38N4O2S
IUPAC name	N-[2-[4-[[(3-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)amino]methyl]piperidin-1-yl]ethyl]naphthalene-1-sulfonamide
Molecular weight	506.709
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	4.6
Synonyms	Naphthalene-1-sulfonic acid (2-{4-[(3-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-ylamino)-methyl]-piperidin-1-yl}-ethyl)-amide BDBM50110414
Inchi Key	BBZYLZUPRQGZEQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H38N4O2S/c30-26-12-11-23-6-3-8-27(20-25(23)19-26)31-21-22-13-16-33(17-14-22)18-15-32-36(34,35)29-10-4-7-24-5-1-2-9-28(24)29/h1-2,4-5,7,9-12,19,22,27,31-32H,3,6,8,13-18,20-21,30H2
PubChem CID	44377691
ChEMBL	CHEMBL164586
IUPHAR	N/A
BindingDB	50110414
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	52.0 nM	PMID11858996	BindingDB,ChEMBL

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