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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Vasopressin V2 receptor
Species	Sus scrofa (Pig)
Gene	AVPR2
Synonym	Antidiuretic hormone receptor AVPR V2 Renal-type arginine vasopressin receptor V2R
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGDGSGVLDCWASFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSLVPGPAERAGGHRGGRRAGSPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQEESCATASSFSARDTSS
UniProt	P32307
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3944
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL264540
Molecular formula	C50H73N9O9S2
IUPAC name	(2R)-1-[(10S,13R,16S,19R,22R)-13-(2-amino-2-oxoethyl)-19-benzyl-22-[(4-ethoxyphenyl)methyl]-12,15,18,21,24-pentaoxo-16-propan-2-yl-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]-N-(5-aminopentyl)pyrrolidine-2-carboxamide
Molecular weight	1008.31
Hydrogen bond acceptor	12
Hydrogen bond donor	8
XlogP	3.1
Synonyms	BDBM50020652 1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide
Inchi Key	BCCJSYKFXXWBSR-TVMZQVGDSA-N
Inchi ID	InChI=1S/C50H73N9O9S2/c1-4-68-35-20-18-34(19-21-35)28-36-44(62)55-37(27-33-15-8-5-9-16-33)46(64)58-43(32(2)3)48(66)56-38(29-41(52)60)45(63)57-39(31-69-70-50(30-42(61)54-36)22-10-6-11-23-50)49(67)59-26-14-17-40(59)47(65)53-25-13-7-12-24-51/h5,8-9,15-16,18-21,32,36-40,43H,4,6-7,10-14,17,22-31,51H2,1-3H3,(H2,52,60)(H,53,65)(H,54,61)(H,55,62)(H,56,66)(H,57,63)(H,58,64)/t36-,37-,38-,39-,40-,43+/m1/s1
PubChem CID	44294592
ChEMBL	CHEMBL264540
IUPHAR	N/A
BindingDB	50020652
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.2 nM	PMID2933517	BindingDB,ChEMBL
Ki	30.0 nM	PMID2933517	BindingDB,ChEMBL

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