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GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Ligand

Nameaminothiazole, 9
Molecular formulaC29H25Cl2N3O3S
IUPAC name3-[[4-[[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-(2,3-dihydro-1H-inden-5-yl)amino]methyl]benzoyl]amino]propanoic acid
Molecular weight566.497
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP7.0
SynonymsSCHEMBL2648679
CHEMBL491352
BDBM29112
Inchi KeyMDDANNKYTHKAHR-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H25Cl2N3O3S/c30-24-11-9-22(15-25(24)31)26-17-38-29(33-26)34(23-10-8-19-2-1-3-21(19)14-23)16-18-4-6-20(7-5-18)28(37)32-13-12-27(35)36/h4-11,14-15,17H,1-3,12-13,16H2,(H,32,37)(H,35,36)
PubChem CID20775916
ChEMBLCHEMBL491352
IUPHARN/A
BindingDB29112
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50638.0 nMPMID19385613BindingDB,ChEMBL

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