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Name | 5-hydroxytryptamine receptor 1B |
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Species | Homo sapiens (Human) |
Gene | HTR1B |
Synonym | 5-HT1B receptor 5-HT-1B 5-HT-1D-beta 5-HT1B Serotonin 1D beta receptor [ Show all ] |
Disease | Chronic schizophrenics Major depressive disorder Migraine headaches Mood disorder Psychotic disorders [ Show all ] |
Length | 390 |
Amino acid sequence | MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS |
UniProt | P28222 |
Protein Data Bank | 4iar, 6g79, 5v54 |
GPCR-HGmod model | P28222 |
3D structure model | This structure is from PDB ID 4iar. |
BioLiP | BL0239857, BL0403524,BL0403525, BL0417722 |
Therapeutic Target Database | T07806 |
ChEMBL | CHEMBL1898 |
IUPHAR | 2 |
DrugBank | BE0000797 |
Name | LY334370 |
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Molecular formula | C21H22FN3O |
IUPAC name | 4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide |
Molecular weight | 351.425 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 3.6 |
Synonyms | 182563-08-2 5Q7I1WL2UY D09GHO LY-334370 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1h-indol-5-yl]-benzamide [ Show all ] |
Inchi Key | MDMJLMDBRQXOOI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26) |
PubChem CID | 5311258 |
ChEMBL | CHEMBL101690 |
IUPHAR | 20, 151 |
BindingDB | 50130461 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 83.0 nM | PMID18507369 | PDSP,BindingDB,ChEMBL |
Ki | 240.0 nM | PMID15546719, PMID12825944 | BindingDB,ChEMBL |
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