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Name | P2Y purinoceptor 14 |
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Species | Mus musculus (Mouse) |
Gene | P2ry14 |
Synonym | G protein-coupled receptor 105 G-protein coupled receptor 105 GPR105 G protein coupled receptor for UDP-glucose P2Y purinoceptor 14 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 338 |
Amino acid sequence | MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL |
UniProt | Q9ESG6 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1770046 |
IUPHAR | 330 |
DrugBank | N/A |
Name | CHEMBL1774899 |
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Molecular formula | C25H17F3O4S |
IUPAC name | 4-(4-methylsulfonylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid |
Molecular weight | 470.462 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 6.1 |
Synonyms | BDBM50343884 4-(4-(methylsulfonyl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid |
Inchi Key | MEVAMFHWVSTRKE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H17F3O4S/c1-33(31,32)21-9-4-16(5-10-21)23-14-19(24(29)30)13-18-12-17(6-11-22(18)23)15-2-7-20(8-3-15)25(26,27)28/h2-14H,1H3,(H,29,30) |
PubChem CID | 54585843 |
ChEMBL | CHEMBL1774899 |
IUPHAR | N/A |
BindingDB | 50343884 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 20.0 nM | PMID21507640 | BindingDB,ChEMBL |
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