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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCHEMBL517733
Molecular formulaC27H29Cl2N3
IUPAC name[(1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-(3-methylpyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl]methanamine
Molecular weight466.45
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP6.0
SynonymsBDBM50245979
(rel)-(8-(bis(2-chlorophenyl)methyl)-3-(3-methylpyridin-2-yl)-8-aza-bicyclo[3.2.1]octan-3-yl)methanamine
Inchi KeyBDBVMIPKTBKEGG-PMACEKPBSA-N
Inchi IDInChI=1S/C27H29Cl2N3/c1-18-7-6-14-31-26(18)27(17-30)15-19-12-13-20(16-27)32(19)25(21-8-2-4-10-23(21)28)22-9-3-5-11-24(22)29/h2-11,14,19-20,25H,12-13,15-17,30H2,1H3/t19-,20-/m0/s1
PubChem CID44562791
ChEMBLN/A
IUPHARN/A
BindingDB50245979
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki50.0 nMPMID18990569BindingDB

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