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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL48129
Molecular formula	C32H46NO5PS
IUPAC name	(3-hexadecoxyphenyl) [3-(1,3-thiazol-3-ium-3-ylmethyl)phenyl] phosphate
Molecular weight	587.756
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	11.0
Synonyms	BDBM50006060 3-{3-[(3-Hexadecyloxy-phenoxy)-hydroxy-phosphoryloxy]-benzyl}-thiazol-3-ium
Inchi Key	BDMQKAMNSQGYIN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C32H46NO5PS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-23-36-30-19-17-21-32(26-30)38-39(34,35)37-31-20-16-18-29(25-31)27-33-22-24-40-28-33/h16-22,24-26,28H,2-15,23,27H2,1H3
PubChem CID	14992401
ChEMBL	CHEMBL48129
IUPHAR	N/A
BindingDB	50006060
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1810.0 nM	PMID1578493	BindingDB,ChEMBL

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