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Name | Alpha-1A adrenergic receptor |
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Species | Oryctolagus cuniculus (Rabbit) |
Gene | ADRA1A |
Synonym | Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MVFLSGNASDSSNCTHPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVISIDRYIGVSYPLRYPTIVTQRRGLRALLCVWAFSLVISVGPLFGWRQPAPDDETICQINEEPGYVLFSALGSFYVPLTIILAMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGVASAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALGYTLHAPSQALEGQHKDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPRGSARITVPKDQSACTTARVRSKSFLQVCCCVGPSTPNPGENHQVPTIKIHTISLSENGEEV |
UniProt | O02824 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3637 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL91326 |
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Molecular formula | C24H34N4O2 |
IUPAC name | 2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-N,N,3-trimethylbenzamide |
Molecular weight | 410.562 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | 2-{3-[4-(2-methoxy-phenyl)piperazin-1-yl]propylamino}-N,N,3-trimethylbenzamide 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N,3-trimethylbenzamide ADBSINZYBRTZMT-UHFFFAOYSA-N SCHEMBL9027286 |
Inchi Key | ADBSINZYBRTZMT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H34N4O2/c1-19-9-7-10-20(24(29)26(2)3)23(19)25-13-8-14-27-15-17-28(18-16-27)21-11-5-6-12-22(21)30-4/h5-7,9-12,25H,8,13-18H2,1-4H3 |
PubChem CID | 21473427 |
ChEMBL | CHEMBL91326 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 3.162 nM | PMID9276013 | ChEMBL |
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