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GPCR

NameCholecystokinin receptor type A
SpeciesRattus norvegicus (Rat)
GeneCckar
SynonymCCK-A receptor
CCK-AR
CCK1 receptor
CCK1-R
cholecystokinin receptor type A
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
UniProtP30551
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2871
IUPHAR76
DrugBankN/A

Ligand

NameCHEMBL277661
Molecular formulaC22H18N2O4
IUPAC name(3S,4S)-4-(naphthalene-2-carbonylamino)-5-oxo-1-phenylpyrrolidine-3-carboxylic acid
Molecular weight374.396
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.4
Synonyms(3S,4S)-4-[(Naphthalene-2-carbonyl)-amino]-5-oxo-1-phenyl-pyrrolidine-3-carboxylic acid
BDBM50280133
SCHEMBL9205637
Inchi KeyBDVFAVBKAXMDIW-OALUTQOASA-N
Inchi IDInChI=1S/C22H18N2O4/c25-20(16-11-10-14-6-4-5-7-15(14)12-16)23-19-18(22(27)28)13-24(21(19)26)17-8-2-1-3-9-17/h1-12,18-19H,13H2,(H,23,25)(H,27,28)/t18-,19-/m0/s1
PubChem CID44458112
ChEMBLCHEMBL277661
IUPHARN/A
BindingDB50280133
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED500.41 mg.kg-1Bioorg. Med. Chem. Lett., (1992) 2:10:1251ChEMBL
ED501.8 mg.kg-1Bioorg. Med. Chem. Lett., (1992) 2:10:1251ChEMBL
IC5016.0 nM, Bioorg. Med. Chem. Lett., (1992) 2:10:1251BindingDB,ChEMBL

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