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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

Namecarboxylic acid agonist, 32
Molecular formulaC16H16FNO2
IUPAC name3-[4-[(3-fluorophenyl)methylamino]phenyl]propanoic acid
Molecular weight273.307
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.3
SynonymsCHEMBL414895
3-(4-{[(3-fluorophenyl)methyl]amino}phenyl)propanoic acid
BDBM22515
Inchi KeyBEDDMAWVXRZLSZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H16FNO2/c17-14-3-1-2-13(10-14)11-18-15-7-4-12(5-8-15)6-9-16(19)20/h1-5,7-8,10,18H,6,9,11H2,(H,19,20)
PubChem CID24825497
ChEMBLCHEMBL414895
IUPHARN/A
BindingDB22515
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
%max120.0 %PMID17240142ChEMBL
EC505011.87 nMPMID17240142ChEMBL
EC505012.0 nMPMID17240142BindingDB

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