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GPCR

NameProstaglandin E2 receptor EP1 subtype
SpeciesHomo sapiens (Human)
GenePTGER1
SynonymPGE receptor EP1 subtype
EP1 receptor
prostaglandin E receptor 1 (subtype EP1), 42kDa
Prostanoid EP1 receptor
EP1 prostanoid receptor
[ Show all ]
DiseaseUnspecified
Thrombosis
Pollakiuria
Pain
Length402
Amino acid sequenceMSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProtP34995
Protein Data BankN/A
GPCR-HGmod modelP34995
3D structure modelThis predicted structure model is from GPCR-EXP P34995.
BioLiPN/A
Therapeutic Target DatabaseT15497
ChEMBLCHEMBL1811
IUPHAR340
DrugBankBE0000064

Ligand

NameCHEMBL228963
Molecular formulaC27H21ClN2O3
IUPAC name6-[2-(5-chloro-2-phenylmethoxyphenyl)-5-methylpyrrol-1-yl]-1H-indole-4-carboxylic acid
Molecular weight456.926
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP6.1
SynonymsBEHWVVDVWLWXCI-UHFFFAOYSA-N
SCHEMBL5628787
6-{2-[5-Chloro-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1-yl}-1H-indole-4carboxylic acid
BDBM50422977
Inchi KeyBEHWVVDVWLWXCI-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H21ClN2O3/c1-17-7-9-25(30(17)20-14-22(27(31)32)21-11-12-29-24(21)15-20)23-13-19(28)8-10-26(23)33-16-18-5-3-2-4-6-18/h2-15,29H,16H2,1H3,(H,31,32)
PubChem CID10456789
ChEMBLCHEMBL228963
IUPHARN/A
BindingDB50422977
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501.259 nMPMID17175160ChEMBL
IC501.3 nMPMID17175160BindingDB

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