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Name | D(1A) dopamine receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Drd1 |
Synonym | D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 446 |
Amino acid sequence | MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST |
UniProt | P18901 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL265 |
IUPHAR | 214 |
DrugBank | N/A |
Name | CHEMBL136468 |
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Molecular formula | C22H26ClFN2 |
IUPAC name | 4-[6-chloro-3-(2-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine |
Molecular weight | 372.912 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 4.8 |
Synonyms | BDBM50029405 SCHEMBL8107803 4-[6-Chloro-3-(2-fluoro-phenyl)-indan-1-yl]-1,2,2-trimethyl-piperazine |
Inchi Key | BEJFETGIBLFMPS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H26ClFN2/c1-22(2)14-26(11-10-25(22)3)21-13-18(17-6-4-5-7-20(17)24)16-9-8-15(23)12-19(16)21/h4-9,12,18,21H,10-11,13-14H2,1-3H3 |
PubChem CID | 10809335 |
ChEMBL | CHEMBL136468 |
IUPHAR | N/A |
BindingDB | 50029405 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
ED50 | <17.0 umol.kg-1 | PMID7473566 | ChEMBL |
IC50 | 4.4 nM | PMID7473566 | BindingDB,ChEMBL |
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