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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL268516
Molecular formula	C27H27N7O2
IUPAC name	(2R)-2-amino-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide
Molecular weight	481.56
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	2.9
Synonyms	SCHEMBL9025303
Inchi Key	MWQYKBWDPLRJJV-UZUQRXQVSA-N
Inchi ID	InChI=1S/C27H27N7O2/c1-17(28)26(35)29-23-15-14-20-6-2-5-9-24(20)34(27(23)36)16-18-10-12-19(13-11-18)21-7-3-4-8-22(21)25-30-32-33-31-25/h2-13,17,23H,14-16,28H2,1H3,(H,29,35)(H,30,31,32,33)/t17-,23-/m1/s1
PubChem CID	18651340
ChEMBL	CHEMBL268516
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	0.1 uM	Bioorg. Med. Chem. Lett., (1994) 4:9:1117	ChEMBL
ED50	1.4 uM	Bioorg. Med. Chem. Lett., (1994) 4:9:1117	ChEMBL

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