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GLASS

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GPCR

Name	Trace amine-associated receptor 1
Species	Macaca mulatta (Rhesus macaque)
Gene	TAAR1
Synonym	TaR-1 Trace amine receptor 1
Disease	N/A for non-human GPCRs
Length	338
Amino acid sequence	MPFCHNIINISCVKNNWSNDVRASLYSLMALIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKINILVVCVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLAFMTSFYIPGSIMLCIYYRIYLIAKEQARSINDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFVCTVIDPFLHYTIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMILFGKIFQKDSSRCKLFLESSS
UniProt	Q8HZ64
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1926495
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	METHAMPHETAMINE
Molecular formula	C10H15N
IUPAC name	(2S)-N-methyl-1-phenylpropan-2-amine
Molecular weight	149.237
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.1
Synonyms	45952-89-4 Methamphetaminum [INN-Latin] Benzeneethanamine, N,.alpha.-dimethyl-, (S)- N-Methyl-1-phenyl-2-propanamine # Benzeneethanamine,.alpha.-dimethyl-, (S)- NSC25115 Crystal Meth Phenethylamine, N,alpha-dimethyl-, (S)-(+)- d-Methamphetamine Speed D08187 Desyphed (+)-N,.alpha.-Dimethyl-.beta.-phenylethylamine ICE [Street Name] (S)-(+)-Deoxyephedrine Metamfetamine [INN] 1-Phenyl-2-methylamino-propan Metanfetamina [Spanish] ZINC6021043 Methamfetamine AC1L1W1Z Methyl-beta-phenylisopropylamine Benzeneethanamine, N,alpha-dimethyl-, (alphaS)- (9CI) N-Methyl-beta-phenylisopropylamine CHEBI:6809 PDSP2_001388 D-1-Phenyl-2-methylaminopropan Phenethylamine,.alpha.-dimethyl-, (+)- d-N,a-dimethylphenethylamine UNII-13ZT6YG5SD component MYWUZJCMWCOHBA-VIFPVBQESA-N DB01577 (+)-(S)-N-.alpha.-Dimethylphenethylamine dextromethamphetamine (+)-N,alpha-Dimethyl-beta-phenylethylamine LS-103331 (S)-Methamphetamine Metamfetaminum [INN-Latin] 139-47-9 2S-(+)-Methamphetamine Methamphetamine, its salts, isomers, and salts of its isomers BDBM50359499 MYWUZJCMWCOHBA-VIFPVBQESA-N Benzeneethanamine, N,alpha-dimethyl-, (S)-(9CI) NSC 25115 Crank Phenethylamine, N,.alpha.-dimethyl-, (S)-(+)- d-Deoxyephedrine S-(+)-Methamphetamine d-Phenylisopropylmethylamine Desoxyephedrine hydrochloride (Salt/Mix) (+)-methamphetamine Epitope ID:178090 (2S)-N-methyl-1-phenylpropan-2-amine Metamfetamine (S)-N,alpha-Dimethylbenzeneethanoamine Metanfetamina UNII-44RAL3456C Methamphetaminum [JP] Benzeneethanamine, N,alpha-dimethyl-, (+)- N-Methyl-beta-phenylisopropylamin C07164 PDSP1_001404 Crystal Meth [Street Name] Phenethylamine, N,alpha-dimethyl-, (S)-(+)- (8CI) d-Methylamphetamine Speed [Street Name] D0P6UB (+ )-Methylamphetamine Desyphed hydrochloride (+)-N,.alpha.-Dimethylphenethylamine intra-venous methamphetamine (S)-(+)-Methamphetamine Metamfetamine-m 1-Phenyl-2-methylamino-propan [German] Meth AC1Q4SVR Methylamphetamine Benzeneethanamine, N,alpha-dimethyl-, (alphaS)-(9CI) N-Methylamphetamine PDSP2_001389 d-1-Phenyl-2-methylaminopropan [German] Phenethylamine,.alpha.-dimethyl-, (S)-(+)- D-N,alpha-dimethylphenethylamine DEA No. 1105 (+)-(S)-N-alpha-Dimethylphenethylamine DTXSID8037128 (+)-N,alpha-Dimethylphenethylamine Metamfetamina (S)-Methylamphetamine Metamfetaminum [Latin] 14611-50-8 44RAL3456C Methamphetaminum Benzeneethanamine, N,.alpha.-dimethyl-, (+)- N-Methyl-1-phenyl-2-propanamine Benzeneethanamine,.alpha.-dimethyl-, (+)- NSC-25115 Crank [Street Name] Phenethylamine, N,alpha-dimethyl-, (+)- d-Desoxyephedrine SCHEMBL42615 D03FPU Desoxyn (TN) (+)-Methylamphetamine HSDB 3359 (alphaS)-N,alpha-dimethylbenzeneethanamine Metamfetamine (INN) (S)-N-methyl-1-phenylpropan-2-amine Metanfetamina [INN-Spanish] WLN: 1MY1&1R -D Meth (Street Name) 537-46-2 Methyl-.beta.-phenylisopropylamine Benzeneethanamine, N,alpha-dimethyl-, (alphaS)- N-Methyl-beta-phenylisopropylamin [German] C10H15N PDSP1_001405 d-(S)-Methamphetamine Phenethylamine, N,alpha-dimethyl-, (S)-(+)-(8CI) d-N,.alpha.-Dimethylphenethylamine Stimulex (+)-(S)-Deoxyephedrine Desyphed hydrochloride (Salt/Mix) (+)-N,.alpha.-Dimethylphenethylamine hydrochloride (Salt/Mix) L-Methamphetamine (S)-(+)-N,alpha,dimethylphenethylamine Metamfetaminum 1-Phenyl-2-methylaminopropane Methamphetamine hydrochloride B40 methyl[(2S)-1-phenylpropan-2-yl]amine Benzeneethanamine, N,alpha-dimethyl-, (S)- Norodin CHEMBL1201201 Phenethylamine, N,.alpha.-dimethyl-, (+)- D-1-Phenyl-2-methylaminopropane S(+)-Methamphetamine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material d-N-Methylamphetamine desohyephedrine (+)-2-(N-Methylamino)-1-phenylpropane EINECS 208-668-7 (+)-N-Methylamphetamine Metamfetamina [INN-Spanish] (S)-N,alpha-Dimethylbenzeneethanamine Metamphetamine 1690-86-4 [ Show all ]
Inchi Key	MYWUZJCMWCOHBA-VIFPVBQESA-N
Inchi ID	InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1
PubChem CID	10836
ChEMBL	CHEMBL1201201
IUPHAR	N/A
BindingDB	50359499
DrugBank	DB01577
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5300.0 nM	PMID22037049	BindingDB,ChEMBL

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