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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL451796
Molecular formula	C20H21N7O5
IUPAC name	ethyl 1-[5-nitro-6-[4-(1,2,4-triazol-1-yl)phenoxy]pyrimidin-4-yl]piperidine-4-carboxylate
Molecular weight	439.432
Hydrogen bond acceptor	10
Hydrogen bond donor	0
XlogP	2.8
Synonyms	SCHEMBL388790 1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester BDBM50244588
Inchi Key	BEQXVWQBFMRYNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21N7O5/c1-2-31-20(28)14-7-9-25(10-8-14)18-17(27(29)30)19(23-12-22-18)32-16-5-3-15(4-6-16)26-13-21-11-24-26/h3-6,11-14H,2,7-10H2,1H3
PubChem CID	10003301
ChEMBL	CHEMBL451796
IUPHAR	N/A
BindingDB	50244588
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2500.0 nM	PMID18698756	BindingDB,ChEMBL

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